| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Cerebral hypothermia has been evaluated and used for clinical application of hypoxic-ischemic encephalopathy, cerebral edema, and cerebral infarction due to inflammation after brain injury. Recently, apoptosis induced by depletion of epidermal growth factor (EGF) in neural stem cell line (MEB5) has also reported to be suppressed under similar culture condition to cerebral hypothermia. However, the regulation mechanism of apoptosis in MEB5 under hypothermia condition is still unknown. In this study, we analyzed glycolipid composition and glycoproteins in MEB5 after culture under cerebral hypothermia condition and found that these glycoconjugates would be related to the regulation mechanism of apoptosis.
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