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Estimation of Biocompatibility of Polymeric Materials without Living Cells

Research Project

Project/Area Number 24750216
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Polymer/Textile materials
Research InstitutionUniversity of Toyama

Principal Investigator

GEMMEI Makoto  富山大学, 大学院理工学研究部(工学), 准教授 (70334711)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords高分子機能材料 / 生体適合性 / 表面の水
Research Abstract

Attenuated total reflectance (ATR) near infrared (NIR) and middle infrared (MIR) spectroscopes, which have the ability to observe the water-solid interface selectively, were constructed. Using ATR-NIR, a combination band (7000 cm-1) of OH symmetric and asymmetric stretching of water on hydrophilic (silanol) and hydrophobic (alkylated) solid surfaces was obtained. The ATR-NIR spectra indicated that the density of water on both the hydrophilic and hydrophobic surfaces increased in the range of 100 nm from the surface. Using ATR-MIR, amide I (1650 cm-1) and amide II (1550 cm-1) bands of the protein adsorbed on the surface were obtained. Structural change of the adsorbed protein on the hydrophobic surface was faster than that on the hydrophilic surface. A good correlation between the water structures and the structural changes of an adsorbed protein on the hydrophilic / hydrophobic surfaces was not observed.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method2014

    • Author(s)
      Kondo, T.; Nomura, K.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 113 Pages: 361-367

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sum-frequency Generation Analyses on the Structure of Water at Amphoteric SAM-Liquid Water Interfaces2014

    • Author(s)
      Nomura, K.; Nakaji-Hirabayashi, T.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sum-frequency Generation Analyses on the Structure of Water at Amphoteric SAM-Liquid Water Interfaces.2014

    • Author(s)
      Noura, K.; Nakaji-Hirabayashi, T.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method.2014

    • Author(s)
      Kondo, T.; Nomura, K.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: 113 Pages: 361-367

    • DOI

      10.1016/j.colsurfb.2013.08.051

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-Step Recrystallization of Water in Concentrated Aqueous Solution of Poly(ethylene glycol)2013

    • Author(s)
      Gemmei-Ide, M.; Kasai, R.; Motonaga, T.; Kitano, H
    • Journal Title

      J. Phys. Chem. B.

      Volume: 117 Pages: 2688-2694

    • Related Report
      2013 Final Research Report
  • [Journal Article] Two-Step Recrystallization of Water in Concentrated Aqueous Solution of Poly(ethylene glycol).2013

    • Author(s)
      Gemmei-Ide, M.; Motonaga, T.; Kasai, R.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B.

      Volume: 117 Issue: 7 Pages: 2188-2194

    • DOI

      10.1021/jp3102628

    • NAID

      120006395335

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure of water in the vicinity of a zwitterionic polymer brush as examined by sum frequency generation method2012

    • Author(s)
      Kondo, T.; Nomura, K.; Murou, M.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 100 Pages: 126-132

    • Related Report
      2013 Final Research Report
  • [Journal Article] R ecrystallization of Water in Non-Water- Soluble (Meth)Acrylate Polymers is Not Rare and is Not Devitrification2012

    • Author(s)
      Gemmei-Ide, M.; Ohya, A.; Kitano, H.
    • Journal Title

      J. Phys. Chem. B.

      Volume: 116 Pages: 1850-1857

    • Related Report
      2013 Final Research Report
  • [Journal Article] Binding ofβ-amyloid to sulfated sugar residues in a polymer brush2012

    • Author(s)
      Kitano, H.; Saito, D.; Kamada, T.; Gemmei-Ide, M.
    • Journal Title

      Colloids Surfaces B : Biointerfaces

      Volume: 93 Pages: 219-225

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sum frequency generation study on the structure of water in the vicinity of an amphoteric polymer brush2012

    • Author(s)
      Kondo, T.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B. Biointerfaces

      Volume: 91 Pages: 215-218

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structure of water in the vicinity of a zwitterionic polymer brush as examined by sum frequency generation method2012

    • Author(s)
      Takuya Kondoa, Kouji Nomura, Masanobu Murou, Makoto Gemmei-Ide, Hiromi Kitano, Hidenori Noguchi, Kohei Uosaki, Kohji Ohno, Yoshiyuki Saruwatari
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 100 Pages: 126-132

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 和周波発生分光法による電荷中和された高分子近傍の水の構造に関する研究2012

    • Author(s)
      野村 浩二,近藤 卓也,室生 賢伸,源明 誠,北野 博巳,大野 工司,野口 秀典,魚崎 浩平,猿渡 欣幸
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 双性イオン型高分子中の再結晶化水2012

    • Author(s)
      源明 誠,高谷 務之,堀岡 祐介,北野 博巳
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 材料表面の吸着タンパク質の構造と線維芽細胞の付着特性の相関2012

    • Author(s)
      源明 誠,上條 典昭,北野 博巳
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Book] 「IR分析に関する技術資料」 9章 24節:温度可変赤外分光法による固体高分子中の水の相転移挙動の評価-2014

    • Author(s)
      源明 誠・北野博巳(分担執筆)
    • Total Pages
      785
    • Publisher
      株式会社 技術情報協会
    • Related Report
      2013 Annual Research Report
  • [Book] 温度可変赤外分光法による固体高分子中の水の相転移挙動の評価、「IR分析テクニック事例集」2013

    • Author(s)
      源明誠, 北野博巳
    • Publisher
      株式会社技術情報協会
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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