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Development of sarcomere-like microactuators driven by motor proteins

Research Project

Project/Area Number 24760203
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionGifu University

Principal Investigator

NITTA Takahiro  岐阜大学, 工学部, 助教 (20402216)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsモーター蛋白質 / 細胞骨格 / 微細加工 / マイクロアクチュエータ / シミュレーション / キネシン / 微小管 / アクチュエータ
Outline of Final Research Achievements

Motor proteins, such as kinesin and myosin, are biological molecular machines working in cells, and have been integrated into MEMS and lab-on-a-chips as their driving forces. Here, we aimed at developing a microactuator with motor proteins and cytoskeletal filaments anchored onto microfabricated scaffolds. To this end, we fabricated microscopic cylindrical particles serving as the scaffolds, and bound them with motor proteins and cytoskeletons. In addition, we developed a computer simulation which aids the development of the microactuator.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 4 results)

  • [Journal Article] Understanding the Guiding of Kinesin/Microtubule-Based Microtransporters in Microfabricated Tracks2014

    • Author(s)
      Yuki Ishigure and Takahiro Nitta
    • Journal Title

      Langmuir

      Volume: 30 Issue: 40 Pages: 12089-12096

    • DOI

      10.1021/la5021884

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In silico evolution of guiding track designs for molecular shuttles powered by kinesin motors2013

    • Author(s)
      T. Sunagawa, A. Tanahashi, M. Downs, H. Hess and T. Nitta
    • Journal Title

      Lab on a Chip

      Volume: - Issue: 14 Pages: 2827-2827

    • DOI

      10.1039/c3lc41103f

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] アクチン・ミオシンの工学利用に向けたin vitro運動アッセイのシミュレーション2015

    • Author(s)
      石槫祐貴,新田高洋
    • Organizer
      2015年 生体運動合同班会議
    • Place of Presentation
      東京
    • Year and Date
      2015-01-07 – 2015-01-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Computer Simulation of Reconstitute Systems of Motor Proteins Revealed Biophysical Phenomena Relevant to Biomedical Engineering2014

    • Author(s)
      Takahiro Nitta and Yuki Ishigure
    • Organizer
      2014 International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-09 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computer-aided Design of Microdevices Powered by Biological Molecular Machines2014

    • Author(s)
      Takahiro Nitta
    • Organizer
      IUMRS-ICA 2014
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-24 – 2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Simulating microtransporters driven by biological molecular machines2014

    • Author(s)
      Takahiro Nitta
    • Organizer
      MICRO- AND NANOMACHINES 2014
    • Place of Presentation
      Hannover, Germany
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Guidance of Molecular Shuttles Driven by Kinesin Motor Proteins for Applications to Nanobiosensors: A Simulation Study2014

    • Author(s)
      Yuki Ishigure and Takahiro Nitta
    • Organizer
      Biosensors 2014
    • Place of Presentation
      Melbourne, Austrailia
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Designing microdevices powered by motor proteins2014

    • Author(s)
      Takahiro Nitta
    • Organizer
      International Workshop for Motor Proteins toward Emerging Nano Systems
    • Place of Presentation
      Kyoto University
    • Year and Date
      2014-04-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Three-Dimensional Movements of Microtubule Driven by Kinesin on Microfabricated Tracks Revealed with a Computer Simulation

    • Author(s)
      Yuki Ishigure, Takahiro Nitta
    • Organizer
      第51回生物物理学会年会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Analyzing Three-Dimensional Movements of Molecular Shuttles Driven by Kinesin with Computer Simulation

    • Author(s)
      Yuki Ishigure, Takahiro Nitta
    • Organizer
      24th International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 微細加工基板上のキネシンによって駆動される微小管の滑り運動をシミュレーションする

    • Author(s)
      新田高洋,石槫祐貴
    • Organizer
      2014年生体運動合同班会議
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] モーター蛋白質の工学利用へ向けたキネシン・微小管in vitro motility assayのシミュレーションする

    • Author(s)
      新田高洋,石槫祐貴
    • Organizer
      2013年度生物物理学会中部支部講演会
    • Place of Presentation
      岡崎
    • Related Report
      2013 Research-status Report
  • [Presentation] Designing microdevices powered by motor proteins

    • Author(s)
      Takahiro Nitta
    • Organizer
      International Workshop for Motor Proteins toward Emerging Nano Systems
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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