Functional analysis of relaxins in teleosts

• Project/Area Number: 24770057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphology/Structure
• Research Institution: The University of Tokyo
• Principal Investigator: KUSAKABE Makoto 東京大学, 大気海洋研究所, 助教 (40451893)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: リラキシン / ニューロペプチド / 浸透圧調節 / 真骨魚類 / 配偶子形成

Research Abstract

The results of the changes in relaxin-related peptide gene expression in the brain of the three-spined stickleback with different salinity environment showed that most of the relaxin-related peptides responded to changes in environmental salinity. A relaxin gene expression that is classified as rln3b in the brain of three-spined stickleback in particular has significantly increased with an increase of the environmental salinity. Further, the expression patterns of receptors of relaxin-related genes differ between seawater and freshwater type stickleback. These results support the possibility of osmoregulatory functions of relaxin-related peptides in teleost fish.

Research Products

• [Presentation] 海型・淡水型イトヨの脳におけるリラキシン遺伝子の発現解析 (2014)
  • Author(s): 日下部誠, 石川麻乃, 北野潤
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山大学, 津島キャンパス (口頭発表)
• [Presentation] Possible osmoregulatory functions of relaxins in three-spined stickleback (Gasterosteus aculeatus) (2013)
  • Author(s): Makoto Kusakabe, Asano Ishikawa, Jun Kitano
  • Organizer: 17th International Congress of Comparative Endocrinology (ICCE 2013)
  • Place of Presentation: スペイン・バルセロナ (口頭発表)
• [Presentation] Possible osmoregulatory functions of relaxins in three-spined stickleback (Gasterosteus aculeatus) (2013)
  • Author(s): Makoto Kusakabe, Asano Ishikawa, Jun Kitano
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Universitat de Barcelona, Barcelona, Spain
• [Presentation] 海型・淡水型イトヨの脳におけるリラキシン遺伝子の発現解析 (2013)
  • Author(s): 日下部 誠、石川 麻乃、北野 潤
  • Organizer: 日本動物学会 第 84回 岡山大会
  • Place of Presentation: 岡山大学津島キャンパス、岡山
• [Presentation] Possible osmoregulatory functions of relaxins in three-spined stickleback (Gasterosteus aculeatus) (2013)
  • Author(s): Kusakabe M, Ishikawa A, Kitano J
  • Organizer: 17th International Congress of Comparative Endocrinology
  • Place of Presentation: Barcelona, Spain
• [Presentation] イトヨにおけるリラキシンの生理作用 (2013)
  • Author(s): 日下部誠、石川麻乃、北野潤
  • Organizer: 日本動物学会 第84回 岡山大会 2013
  • Place of Presentation: 岡山