| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
Our bodies are always exposed to various pressures. The defect of adaptation to these pressures may affect numerous cellular functions and lead to disease. In the present study, we attempted to clarify the biological significance of the EGO complex and unknown function genes, YPR153W and MTC6, in high-pressure growth. As a result, we found that EGO complex-dependent target of rapamycin complex 1 (TORC1) activation is essential for high-pressure growth. In addition, we also suggested that the functions of endoplasmic reticulum resident proteins, Ypr153w and Mtc6, are involved in the adaptation of high-pressure stress. Especially, EGO cmplex-TORC1 pathway is conserved in mammalian cells. These results are useful for analyzing the effect of high-pressure stress to mammalian cells.
|
