Adaptation mechanism to high-pressure stress in Saccharomyces cerevisiae
Project/Area Number |
24780077
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied microbiology
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Research Institution | Aoyama Gakuin University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 圧力生物学 / 出芽酵母 / 圧力生理学 |
Outline of Final Research Achievements |
Our bodies are always exposed to various pressures. The defect of adaptation to these pressures may affect numerous cellular functions and lead to disease. In the present study, we attempted to clarify the biological significance of the EGO complex and unknown function genes, YPR153W and MTC6, in high-pressure growth. As a result, we found that EGO complex-dependent target of rapamycin complex 1 (TORC1) activation is essential for high-pressure growth. In addition, we also suggested that the functions of endoplasmic reticulum resident proteins, Ypr153w and Mtc6, are involved in the adaptation of high-pressure stress. Especially, EGO cmplex-TORC1 pathway is conserved in mammalian cells. These results are useful for analyzing the effect of high-pressure stress to mammalian cells.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae.2014
Author(s)
Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F., and Inokuchi, J.
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Journal Title
J. Lipid Res.
Volume: 55
Issue: 7
Pages: 1343-1356
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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