The study of inhibitory mechanism of bovine milk lactophorin, which is independent of the binding to virion
| Project/Area Number |
24780124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Gifu University |
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Principal Investigator |
INAGAKI Mizuho 岐阜大学, (連合)農学研究科(研究院), 学術研究補佐員 (50626356)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ラクトフォリン / ヒトロタウイルス / 感染症 / 糖鎖 / 牛乳 |
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| Research Abstract |
Human rotavirus (HRV) is a major etiologic agent of severe infantile gastroenteritis. In our previous study, we have found that bovine milk lactophorin (LP) exhibited inhibitory activity against HRV infection. In this study, we demonstrated that LP inhibits the synthesis and assembly of viral protein without contact between LP and virion. It indicated that LP has a unique inhibition mechanism against HRV infection.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Bovine κ-casein inhibits human rotavirus (HRV) infection via direct binding of glycans to HRV2014
Author(s)
Inagaki, M., Muranishi, H., Yamada, K., Kakehi, K., Uchida, K., Suzuki, T., Yabe, T., Nakagomi, T., Nakagomi, O. and Kanamaru, Y
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Journal Title
Journal of Dairy Science
Volume: 97
Issue: 5
Pages: 2653-2661
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The inhibitory mechanism of bovine lactophorin against human rotavirus gastroenteritis2012
Author(s)
Mizuho Inagaki, Shohei Ohno, Keita Yamada, Takeshi Takahashi, Tsukasa Matsuda, Tomio Yabe, Tohru Suzuki, Makoto Sugiyama, Toyoko Nakagomi, Osamu Nakagomi, and Yoshihiro Kanamaru
Organizer
World Congress of Microbes 2012
Place of Presentation
Guangzhou, China
Related Report
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[Presentation] The inhibitory mechanism of bovine lactophorin against human rotavirus gastroenteritis2012
Author(s)
Mizuho Inagaki, Shohei Ohno, Keita Yamada, Takeshi Takahashi, Tsukasa Matsuda, Tomio Yabe, Tohru Suzuki, Makoto Sugiyama, Toyoko Nakagomi, Osamu Nakagomi, and Yoshihiro Kanamaru
Organizer
World Congress of Microbes-2012, , July 30, 2012
Place of Presentation
Guangzhou, China
Related Report
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