| Project/Area Number |
24780292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Toho University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | アミリン / 内側視索前野 / 養育行動 / 社会環境 / 性差 / 遺伝子改変マウス / 社会行動 |
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| Research Abstract |
Parental behavior is essential for mammalian reproduction, and its plasticity depending on the social experiences has been known. Understanding such mechanisms on the plasticity of parental behavior should contribute the effective reproduction of domestic animals and solve the offsprings' mental problems caused by poor parental care. Amylin is known as feeding control polypeptide, expressed in the brain center of the parental behavior, the medial preoptic area. In this study, we showed the dynamics of amylin expression related to the reproductive cycle and the cohabitation with others. ICV injection of amylin reduced feeding and aggressive behavior of mice, while the amylin treatment did not altered the parental behavior of mice.
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