In situ suspended state NMR investigation into a solid dipersion after dispersed into water
| Project/Area Number |
24790041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | suspended state NMR / 固体分散体 / 溶解性 / Eudragit / HRMAS / 固体NMR / 相溶性 / 分子間相互作用 / 溶出速度 / 固体ＮＭＲ / ELSD / 溶解性改善 / 緩和時間 / 過飽和溶液 / NOESY / RFDR / NMR / suspended state NMR法 / In situ測定 / メフェナム酸 |
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| Outline of Final Research Achievements |
Solid dispersion, which is composed of drug and polymer, has been used to improve the solubility and absorption of poorly water soluble drugs. In this study, the structure and state of solid dispersion after dispersed into water was evaluated at molecular level. Here, the advanced techniques of nuclear magnetic resonance (NMR) directly detected the state of both drug and polymer, and the intermolecular interaction between them. Furthermore, the dissolution mechanism of solid dispersion was clarified by simultaneous determination of the dissolution rate of drug and polymer after dispersed the solid dispersion into water.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Effects of the PEG molecular weight of a PEG-lipid and cholesterol on PEG chain flexibility on liposome surfaces2015
Author(s)
Abe, A., Higashi, K., Watabe, K., Kobayashi, A., Limwikrant, W., Yamamoto, K., Moribe, K.
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Journal Title
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume: 474 (5)
Pages: 63-70
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Structural determination of a novel polymorph of sulfathiazole-oxalic acid complex in powder form by solid-state NMR spectroscopy on the basis of crystallographic structure of another polymorph2014
Author(s)
Koike, R., Higashi, K., Liu, N., Limwikrant, W., Yamamoto, K., Moribe, K.
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Journal Title
Cryst. Growth Des.
Volume: 14
Issue: 9
Pages: 4510-4518
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Drug solubilization mechanism of alpha-glucosyl stevia by NMR spectroscopy2014
Author(s)
Zhang, J., Higashi, K., Ueda, K., Kadota, K., Tozuka, Y., Limwikrant, W., Yamamoto, K., Moribe, K.
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Journal Title
Int. J. Pharm.
Volume: 465 (1-2)
Issue: 1-2
Pages: 255-261
DOI
Related Report
Peer Reviewed
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