| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Solid dispersion, which is composed of drug and polymer, has been used to improve the solubility and absorption of poorly water soluble drugs. In this study, the structure and state of solid dispersion after dispersed into water was evaluated at molecular level. Here, the advanced techniques of nuclear magnetic resonance (NMR) directly detected the state of both drug and polymer, and the intermolecular interaction between them. Furthermore, the dissolution mechanism of solid dispersion was clarified by simultaneous determination of the dissolution rate of drug and polymer after dispersed the solid dispersion into water.
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