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Examination of nano-particles contained in food and food packaging material in mice with drugs or chemicals induced toxicity.

Research Project

Project/Area Number 24790127
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental pharmacy
Research InstitutionTeikyo Heisei University

Principal Investigator

ISODA Katsuhiro  帝京平成大学, 薬学部, 講師 (60423117)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords毒性学 / 食品衛生学
Research Abstract

Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. This research examined the safety of the nanoparticle contained in food or a food additive. The Result, silica nano-particles, clay nano-particles, silver nano-particles and platinum nano-particles did not have injury by oral administration to mice, but liver and renal damage were observed in tail vein administration to mice.Our findings suggest that there are the safety of the nanomaterial contained in food and also the necessity of inquiring.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles2013

    • Author(s)
      Isoda K., Tetsuka E., Shimizu Y., Saitoh K., Ishida I., Tezuka M
    • Journal Title

      Biol. Pharm. Bull

      Volume: 36 Pages: 370-375

    • NAID

      40019588231

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of nano-polystyrene particles in inducing cytotoxicity in mice co-injection with cisplatin, or paraquat2013

    • Author(s)
      Isoda K., Shimizu Y., Nishimura N., Tezuka M., Ishida I
    • Journal Title

      Toxicology Letters

      Volume: 221S Pages: 242-242

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver injury induced by thirty- and fifty-nanometer-diameter silica nanoparticles.2013

    • Author(s)
      29. Isoda K., Tetsuka E., Shimizu Y., Saitoh K., Ishida I., Tezuka M.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 36 Pages: 370-375

    • NAID

      40019588231

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of nano-polystyrene particles in inducing cytotoxicity in mice co-injection with cisplatin, or paraquat.2013

    • Author(s)
      Isoda K., Shimizu Y., Nishimura N., Tezuka M., Ishida I.
    • Journal Title

      Toxicology Letters

      Volume: 221S Pages: 242-242

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat2012

    • Author(s)
      Shimizu Y., Isoda K., Tezuka E., Yufu T., Nagai Y., Ishida I., Tezuka M
    • Journal Title

      Pharmazie

      Volume: 67(8) Pages: 712-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat.2012

    • Author(s)
      Shimizu Y., Isoda K., Tezuka E., Yufu T., Nagai Y., Ishida I., Tezuka M
    • Journal Title

      Pharmazie

      Volume: 67(8) Pages: 712-714

    • Related Report
      2012 Research-status Report
  • [Presentation] ナノ白金粒子の薬物相互作用に関する検討2014

    • Author(s)
      磯田勝広、油科香里、赤浦広紀、西村哲治、手塚雅勝、吉岡靖雄、堤康央、石田功
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2014-03-28
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 銀ナノ粒子とナノシリカ粒子の細胞毒性評価に関する研究2013

    • Author(s)
      松永浩明、磯田勝広、赤浦広紀、山本峻大、永田隆太郎、西村哲治、手塚雅勝、石田功
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京都板橋区
    • Year and Date
      2013-10-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 銀ナノ粒子と医薬品における相互作用の検討2013

    • Author(s)
      渡會遥,磯田勝広,蓑毛詩乃,青野豊大,手塚雅勝,石田功
    • Organizer
      第40回日本毒性学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2013-06-17
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 銀ナノ粒子と薬物による相互作用の安全性評価2013

    • Author(s)
      青野豊大,磯田勝広,蓑毛詩乃,渡會遥,手塚雅勝,石田功
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Influence of nano-size polystyrene particles in mice with cisplatin, paraquat or acetaminophen2013

    • Author(s)
      Katsuhiro Isoda, Tetsuji Nishimura, Masakatsu Tezuka and Isao Ishida
    • Organizer
      The 6th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Final Research Report
  • [Presentation] 投与経路による銀ナノ粒子の安全性と薬物相互作用の検討2013

    • Author(s)
      磯田勝広,渡會遥,赤浦広紀、松永浩明、西村哲治、石田功、手塚雅勝
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 経口投与によるナノシリカの安全性評価2013

    • Author(s)
      山本峻大,磯田勝広,赤浦広紀,松永浩明,永田隆太郎,西村哲治,手塚雅勝,石田功
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin or paraquat2013

    • Author(s)
      Katsuhiro Isoda, Yoshimi Shimizu, Tetsuji Nishimura, Masakatsu Tezuka, Isao Ishida
    • Organizer
      49th-Congress of the European Societies of Tovicology
    • Place of Presentation
      Interlaken, Switzerland
    • Related Report
      2013 Final Research Report
  • [Presentation] 経口投与によるナノシリカの安全性評価2013

    • Author(s)
      山本 峻大,磯田 勝広,赤浦 広紀,松永 浩明,永田 隆太郎,西村 哲治,手塚 雅勝,石田 功
    • Organizer
      フォーラム2013 衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 投与経路による銀ナノ粒子の安全性と薬物相互作用の検討2013

    • Author(s)
      磯田 勝広,渡會 遥,赤浦広紀、松永浩明、西村哲治、石田 功、手塚 雅勝
    • Organizer
      フォーラム2013 衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat2013

    • Author(s)
      Katsuhiro Isoda, Yoshimi Shimizu, Tetsuji Nishimura, Masakatsu Tezuka, Isao Ishida.
    • Organizer
      49th-Congress of the European Societies of Tovicology
    • Place of Presentation
      Interlaken, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of nano-size polystyrene particles in mice with cisplatin, paraquat or acetaminophen2013

    • Author(s)
      Katsuhiro Isoda, Tetsuji Nishimura, Masakatsu Tezuka and Isao Ishida.
    • Organizer
      The 6th International Symposium on Nanotechnology,Occupational and Environmental Health
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
  • [Presentation] 銀ナノ粒子と薬物による相互作用の安全性評価2013

    • Author(s)
      青野 豊大,磯田 勝広,蓑毛 詩乃,渡會 遥,手塚 雅勝,石田 功
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      神奈川県横浜市 発表場所 パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Influence of 50-nm polystyrene particles in inducing cytotoxicity in mice co-injected with carbon tetrachloride, cisplatin, or paraquat2013

    • Author(s)
      Katsuhiro Isoda, Yoshimi Shimizu, Tetsuji Nishimura, Masakatsu Tezuka, Isao Ishida.
    • Organizer
      49th Congress of the European Societies of Toxicology
    • Place of Presentation
      Interlaken, Switzerland
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノサイズ銀粒子の安全性評価2012

    • Author(s)
      蓑毛詩乃,青野豊大,渡會遥、磯田勝広,手塚雅勝,石田功
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京都品川区
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノマテリアルとテトラサイクリンの薬物相互作用による安全性の評価2012

    • Author(s)
      安平勝林、磯田勝広、手塚雅勝、石田功
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京都品川区
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 表面を修飾したナノポリスチレンの薬物相互作用の検討2012

    • Author(s)
      野澤健志、磯田勝広、山本峻大、清水芳実、手塚雅勝、石田功
    • Organizer
      フォーラム2012衛生薬学・環境トキシコロジー
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] :ナノサイズ銀粒子の安全性評価2012

    • Author(s)
      蓑毛 詩乃,青野 豊大,渡會 遥、磯田 勝広,手塚 雅勝,石田 功
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京都品川区 発表場所 昭和大学
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノマテリアルとテトラサイクリンの薬物相互作用による安全性の評価2012

    • Author(s)
      安平勝林、磯田勝広、手塚雅勝、石田功
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京都品川区 発表場所 昭和大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 表面を修飾したナノポリスチレンの薬物相互作用の検討2012

    • Author(s)
      野澤健志、磯田勝広、山本峻大、清水芳実、手塚雅勝、石田功
    • Organizer
      フォーラム2012 衛生薬学・環境トキシコロジー
    • Place of Presentation
      愛知県名古屋市 発表場所 名古屋観光ホテル
    • Related Report
      2012 Research-status Report
  • [Remarks] 帝京平成大学薬学部

    • URL

      http://www.thu.ac.jp/univ/pharmacy/index.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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