Establishment of preliminary environmental risk assessment for chemicals with a biomimetic receptor and high-performance liquid chromatography

• Project/Area Number: 24790135
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental pharmacy
• Research Institution: National Institute for Agro-Environmental Sciences
• Principal Investigator: WATANABE Eiki 独立行政法人農業環境技術研究所, その他部局等, 主任研究員 (30354129)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 環境化学 / 分析化学 / 分子認識素子 / リスク初期評価 / 分析化学手法 / 該当せず

Outline of Final Research Achievements

A preliminary method of forecasting the estrogenic revitalization that is used to evaluate the influence of chemicals on human health or ecosystem was established by combining well-established high-performance liquid chromatography with a biomimetic receptor molecule, "molecularly imprinted polymer" that can be artificially created. The estimated values of the relative revitalization obtained from the proposed method and the well-established bioassay method used as a reference method in this study showed a roughly similar tendency. That is, it was concluded that the proposed method was appropriate as a technique for preliminarily forecasting the estrogenic revitalization.