| Project/Area Number |
24790157
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
YOKOOJI Tomoharu 広島大学, 医歯薬保健学研究院(薬), 助教 (70389120)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 食物アレルゲン / 消化管吸収 / 非ステロイド性抗炎症薬 / エンドサイトーシス / 細胞間隙輸送 / NSAIDs |
|---|
| Research Abstract |
In this study, we examined the absorption pathway(s) of a representative food allergen, lysozyme, and the mechanisms of lysozyme absorption facilitated by non-steroidal anti-inflammatory drugs (NSAIDs) in rats. We showed that lysozyme was absorbed by endocytic and paracellular pathways in the proximal intestine, and the absorption was facilitated by aspirin and diclofenac after impairment of the paracellular pathway. Furthermore, we found that a synthetic prostaglandin-E1 analog, misoprostol suppressed the intestinal absorption of allergens facilitated by aspirin. These findings may help to clarify the pathophysiology of FDEIA and aid its treatment.
|
