| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Carbon monoxide (CO) has potent anti-inflammatory and anti-oxidant effects. We preparate a CO-bound hemoglobin-vesicles (CO-HbV), and evaluated the therapeutic effect of CO-HbV on idiopathic pulmonary fibrosis (IPF) that is thought to involve inflammation and the production of reactive oxygen species (ROS). CO-HbV suppressed the progression of pulmonary fibril formation and improved respiratory function compared to saline and HbV in a bleomycin-induced pulmonary fibrosis mice model. The suppressive effect of CO-HbV on pulmonary fibrosis can be attributed to a decrease in ROS generation by inflammatory cells, cytokines and transforming growth factor-beta in the lung. This is the first demonstration of the inhibitory effect of CO-HbV on the progression of pulmonary fibrosis via the anti-oxidative and anti-inflammatory effects of CO in the bleomycin-induced pulmonary fibrosis mice model.
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