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Useful as the biomarker of neuropeptides on chemotherapy-induced nausea and vomitting

Research Project

Project/Area Number 24790161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionOita University

Principal Investigator

SATO Yuhki  大分大学, 医学部, 副薬剤部長 (00570087)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords神経ペプチド / バイオマーカー / 悪心・嘔吐 / 食欲不振 / がん化学療法による悪心・嘔吐 / 神経内分泌ペプチド / 制吐薬
Research Abstract

Chemotherapy is widely recognized to cause severe gastrointestinal disorders like nausea, vomiting, and appetite loss. The aim of this study was to assess the plasma neuropeptide levels and its association with these during chemotherapy in patients with esophageal cancer. Six patients with esophageal cancer who underwent chemotherapy were enrolled in this study. Plasma neuropeptides levels were measured before and after chemotherapy(total 5 times).There was significantly correlation between plasma ghrelin and substance P, and gastrointestinal disorders. The plasma ghrelin, substance P,and motilin levels in plasma might be good indicators of the expression of the gastrointestinal disorders bychemotherapy in esophageal cancer patients.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2012

All Presentation (6 results)

  • [Presentation] Changes in plasma gastrointestinal peptide levels after platinum-based chemotherapy in esophageal cancer patients2014

    • Author(s)
      Ono Yuko,Yuhki Sato
    • Organizer
      第12回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡(予定)
    • Year and Date
      2014-07-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in plasma gastrointesitinal peptide levels after platinum-based chemotherapy in esophageal cancer patients2014

    • Author(s)
      Yuko Ono, Yuhki Sato, Tomotaka Shibata, Yosuke Suzuki, Ryosuke Tatsuta, Takashi Fujioka, Tsuyoshi Noguchi, Hiroki Itoh
    • Organizer
      第12回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際センター(福岡県・福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん化学療法による悪心・嘔吐に対する制吐療法標準化の有用性の検討2012

    • Author(s)
      佐藤雄己
    • Organizer
      日本医療薬学会第22回年会
    • Place of Presentation
      新潟
    • Year and Date
      2012-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Significant of the institutional antiemetic guidelines for chemotherapy induced nausea and vomiting : Evaluation of efficacy and costs2012

    • Author(s)
      Yuhki Sato
    • Organizer
      第10回日本臨床腫瘍学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Significant of the institutional antiemetic guidelines for chemotherapy induced nausea and vomiting: Evaluation of ifficacy and costs2012

    • Author(s)
      Yuhki Sato, Ryosuke Tatsuta, Ryosuke Nakahara, Satoshi Otsu, Hiroki Itoh, Ryotaro Morinaga, Kuniaki Shirao
    • Organizer
      The 10th Annual meeting of Japanese Society of Medical Oncology
    • Place of Presentation
      Osaka
    • Related Report
      2012 Research-status Report
  • [Presentation] がん化学療法による悪心・嘔吐に対する制吐療法標準化の有用性の検討2012

    • Author(s)
      佐藤雄己、龍田涼佑、中原良介、伊東弘樹
    • Organizer
      日本医療薬学会第22回年会開催
    • Place of Presentation
      新潟県
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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