Function of a helicase-related factor during mouse neural crest development
| Project/Area Number |
24790189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経堤 / 発生 / マウス / 神経堤細胞 |
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| Research Abstract |
Sno1 is expressed in neural crest cells of mouse embryo, and Sno1 conditional KO embryos in neural crest lineage showed increased cell death and hypoplastic craniofacial structure. I found that Sno1 interacts with a Histone binding protein. Sno1 can activate gene transcription, and Sno1-C terminal region accumulates at the site of DNA-double strand breaks. Taken together, Sno1 might be involved in gene transcription and DNA-damage repair in developing neural crest cells.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Gain-of-Function Mutations in RIT1 Cause Noonan Syndrome, a RAS/MAPK Pathway Syndrome2013
Author(s)
Aoki Y, Niihori T, Banio T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T Nakayama K, Inoue S, Watanabe Y, Oeura T, Matsubara Y
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Journal Title
The American Journal of Human Genetics
Volume: Volume 93, Issue 1
Issue: 1
Pages: 173-180
DOI
Related Report
Peer Reviewed
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