• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of the sensor for hypertonicity expressed in AVP neurons and its physiological role

Research Project

Project/Area Number 24790229
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

KAORI Sato-Numata  生理学研究所, 細胞器官研究系, 研究員 (60614196)

Research Collaborator OKADA Yasunobu  総合研究大学院大学, 学長 (10025661)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords高浸透圧センサー / バソプレシン分泌 / 容積調節能 / バソプレシンニューロン / 浸透圧センサー / バソプレシン / カチオンチャネル
Outline of Final Research Achievements

It is well known that many types of mammalian cell sense the change of plasma osmolarity and regulate their cell volume to keep cell volume homeostasis under hyperosmolarity. On the other hand, it was reported that osmosensory SON neurons, including arginine-vasopressin (AVP) neurons which are necessary for regulation of body fluid osmolarity, failed to exhibit cell volume regulation under hypseosmotic conditions. In the present study, in contrast, we find that AVP neurons also have the mechanism of cell volume regulation called regulatory volume increase (RVI). Also, it is suggested that a cation channel activated by hyperosmolarity is involved not only in inhibition of the RVI mechanism but also in the promotion of AVP release from AVP neurons.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis.2014

    • Author(s)
      Sato-Numata K, Numata T, Okada Y
    • Journal Title

      Channels (Austin)

      Volume: 8 Issue: 3 Pages: 278-283

    • DOI

      10.4161/chan.27748

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Exploration of temperature sensitivity and new antagonists of acid-sensitive outwardly rectifying anion channel (ASOR)2015

    • Author(s)
      Kaori Sato-Numata, Tomohiro Numata, Yasunobu Okada
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場(神戸ポートアイランド)(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] AVP neuron has cell volume regulation mechanism under hyperosmotic conditions2014

    • Author(s)
      Kaori Sato-Numata, Yoichi Ueta, Yasunobu Okada
    • Organizer
      第91回 日本生理学会大会
    • Place of Presentation
      鹿児島大学 郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Correlation between the mechanisms for cell volume regulation and for body fluid osmolarity control2014

    • Author(s)
      Yasunobu Okada, Kaori Sato-Numata
    • Organizer
      第91回 日本生理学会大会
    • Place of Presentation
      鹿児島大学 郡元キャンパス(鹿児島県鹿児島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Study on the hypoosmolarity sensing mechanism in arginine-vasopressin neurons: Reexamination on the taurine hypothesis2013

    • Author(s)
      Kaori Sato-Numata, Yoichi Ueta and Yasunobu Okada
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi