Research Project
Grant-in-Aid for Young Scientists (B)
Polyunsaturated fatty acids are essential for the growth and functional development of the brain. The present study aimed to examine the role of polyunsaturated fatty acids as mediator on the learning and memory functions. Omega-3 polyunsaturated fatty acids improve learning memory by increasing brain-derived neurotrophic factor and docosahexaenoic acid-derived metabolites in the hippocampus. Docosahexaenoic acid and eicosapentaenoic acid could be induced neuronal differentiation of cultured neural stem cells via different mechanisms. Free fatty acid-activated G protein-coupled receptor 40 activation enhanced neuronal and glial differentiation. These results indicate that Omega-3 polyunsaturated fatty acids could be involved to improve learning and memory functions via neurogenesis.
All 2014 2013 2012 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 1 results) Presentation (42 results) (of which Invited: 2 results) Book (2 results) Remarks (2 results)
Molecules
Volume: 15 Issue: 3 Pages: 3247-3263
10.3390/molecules19033247
120006901571
Stem Cells International
Volume: 未定 Pages: 490476-490476
10.1155/2013/490476
120007000505
Neurochemical Research
Volume: 38(10) Issue: 10 Pages: 2121-2135
10.1007/s11064-013-1121-1
Medical Gas Research
Volume: 2(1) Issue: 1 Pages: 18-18
10.1186/2045-9912-2-18
https://www.staffsearch.shimane-u.ac.jp/kenkyu/search/detail/1ced59bf6fc49f51c2f902ba654db341/research.html