Polyunsaturated fatty acids: role as a mediator in learning and memory

• Project/Area Number: 24790234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Shimane University
• Principal Investigator: KATAKURA Masanori 島根大学, 医学部, 助教 (40383179)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 多価不飽和脂肪酸 / 神経新生 / ドコサヘキサエン酸 / エイコサペンタエン酸 / 遊離脂肪酸受容体 / fatty acid / docosahexaenoic acid / neurogenesis / docosanoids / 神経幹細胞 / Gタンパク質共役型受容体

Research Abstract

Polyunsaturated fatty acids are essential for the growth and functional development of the brain. The present study aimed to examine the role of polyunsaturated fatty acids as mediator on the learning and memory functions. Omega-3 polyunsaturated fatty acids improve learning memory by increasing brain-derived neurotrophic factor and docosahexaenoic acid-derived metabolites in the hippocampus. Docosahexaenoic acid and eicosapentaenoic acid could be induced neuronal differentiation of cultured neural stem cells via different mechanisms. Free fatty acid-activated G protein-coupled receptor 40 activation enhanced neuronal and glial differentiation. These results indicate that Omega-3 polyunsaturated fatty acids could be involved to improve learning and memory functions via neurogenesis.

Research Products

• [Journal Article] Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model. (2014)
  • Author(s): Katakura M, Hashimoto M, Inoue T, Al Mamun A, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O.
  • Journal Title: Molecules Volume: 15 Issue: 3 Pages: 3247-3263
  • DOI: 10.3390/molecules19033247
  • NAID: 120006901571
  • Peer Reviewed / Open Access
• [Journal Article] Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells. (2013)
  • Author(s): Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Shahdat Hossain, Kentaro Matsuzaki, Osamu Shido
  • Journal Title: Stem Cells International Volume: 未定 Pages: 490476-490476
  • DOI: 10.1155/2013/490476
  • NAID: 120007000505
  • Peer Reviewed
• [Journal Article] Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Leprcp/NDmcr rats (2013)
  • Author(s): Michio Hashimoto, Takayuki Inoue, Masanori Katakura, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, Osamu Shido
  • Journal Title: Neurochemical Research Volume: 38（10） Issue: 10 Pages: 2121-2135
  • DOI: 10.1007/s11064-013-1121-1
  • Peer Reviewed
• [Journal Article] Hydrogen-rich water inhibits glucose and -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. (2012)
  • Author(s): Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido
  • Journal Title: Medical Gas Research Volume: 2(1) Issue: 1 Pages: 18-18
  • DOI: 10.1186/2045-9912-2-18
  • Peer Reviewed
• [Presentation] Activation of G protein-coupled receptor 40, one of free fatty acid receptors, induces the enzymes of polyunsaturated fatty acids synthesis and facilitates differentiation of cultured neural stem cells (2014)
  • Author(s): M. Katakura, M. Hashimoto, K. Matsuzaki, T. Okui, O. Shido
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス(鹿児島)
• [Presentation] Activation of G protein-coupled receptor 40, one of free fatty acid receptors, induces the enzymes of polyunsaturated fatty acids synthesis and facilitates differentiation of cultured neural stem cells (2014)
  • Author(s): Masanori Katakura, Michio Hashimoto, Kentaro Matsuzaki, Toshiyuki Okui, Osamu Shido
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
• [Presentation] ω-3多価不飽和脂肪酸による神経変性疾患・精神疾患の予防効果 (2013)
  • Author(s): 片倉賢紀、橋本道男
  • Organizer: 第一回食と環境、そして高齢化を考える研究会
  • Place of Presentation: ホテル日航金沢(石川)
  • Year and Date: 2013-11-22
• [Presentation] 処方剤としてのn-3系脂肪酸は、エイコサペンタエン酸単剤と異なり、メタボリックシンドロームモデルラットの脳由来栄養因子を増加させ認知機能を改善する (2013)
  • Author(s): 橋本道男、井上隆之、片倉賢紀、田邊洋子、Abdullah Mamun、紫藤治
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2013-03-23
• [Presentation] 高齢者における青魚摂取と無気力との関連 : Shimane CoHRE Study (2013)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、山口修平、並河徹、塩飽邦憲、紫藤治
  • Organizer: 第11回日本機能性食品医用学会総会
  • Place of Presentation: 東京海洋大学品川キャンパス(東京)
• [Presentation] 神経幹細胞の分化における多価不飽和脂肪酸受容体, GPR40の役割 (2013)
  • Author(s): 片倉賢紀、橋本道男、奥井俊之、松崎健太郎、紫藤治
  • Organizer: 第65回日本生理学会中国四国地方会
  • Place of Presentation: 川崎医科大学(岡山)
• [Presentation] 高齢者向けの居住系介護施設等入居者の認知機能と介護者負担におよぼすn-3系脂肪酸と運動の影響 (2013)
  • Author(s): 橋本道男、加藤節司、山口修平、田邊洋子、片倉賢紀、大野美穂、井上佳恵、椎名彦、大倉英久、佐々木祐輔、松井禮子、岩野智栄美、下田友子、笠井宏美、紫藤治
  • Organizer: 日本脂質栄養学会第22回大会
  • Place of Presentation: 高知会館(高知)
• [Presentation] 多価不飽和脂肪酸摂取によるラット骨格筋の筋線維型に及ぼす影響 (2013)
  • Author(s): 井上隆之、片倉賢紀、橋本道男、田邊洋子、Abdullah Al Mamun、大谷浩、紫藤治
  • Organizer: 日本脂質栄養学会第22回大会
  • Place of Presentation: 高知会館(高知)
• [Presentation] 高齢者の精神神経機能と赤血球膜脂肪酸組成との関連 : Shimane CoHRE Study (2013)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、山口修平、並河徹、塩飽邦憲、紫藤治
  • Organizer: 日本脂質栄養学会第22回大会
  • Place of Presentation: 高知会館(高知)
• [Presentation] The Binding of Aβ_<1-42>to Lipid-Rafts containing Detergent Resistant Membranes of RBC Ghost is Enhanced by Dietary Docosahexaenoic Acid in rats : an implication of erythrocyte functions to Alzheimer's Disease (2013)
  • Author(s): 橋本道男、Hossain Shahdat、片倉賢紀、紫藤治
  • Organizer: Alzheimer's Association International Conference (AAIC) 2013
  • Place of Presentation: Boston Convention & Exhibition Center (ボストン/米国)
• [Presentation] Omega-3多価不飽和脂肪酸による神経幹細胞のニューロンへの分化誘導機構 (2013)
  • Author(s): 片倉賢紀、橋本道男、奥井俊之、松崎健太郎、田邊洋子、紫藤治
  • Organizer: 第67回日本栄養食糧学会大会
  • Place of Presentation: 名古屋大学(愛知)
• [Presentation] Role of G protein-coupled receptor 40, a free fatty acid receptor, in the proliferation and differentiation of cultured neural stem cells (2013)
  • Author(s): M. Katakura, M. Hashimoto, K. Matsuzaki, T. Okui, O. Shido
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀(東京)
• [Presentation] 多価不飽和脂肪酸による神経幹細胞の分化制御機構の解析 (2013)
  • Author(s): 片倉賢紀、橋本道男、紫藤治
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡)
• [Presentation] Omega-3多価不飽和脂肪酸による神経幹細胞のニューロンへの分化誘導機構 (2013)
  • Author(s): 片倉賢紀、橋本道男、奥井俊之、松崎健太郎、田邊洋子、紫藤治
  • Organizer: 第67回 日本栄養食糧学会大会
  • Place of Presentation: 名古屋大学（名古屋）
• [Presentation] The Binding of Aβ1-42 to Lipid-Rafts containing Detergent Resistant Membranes of RBC Ghost is Enhanced by Dietary Docosahexaenoic Acid in rats: an implication of erythrocyte functions to Alzheimer’s Disease (2013)
  • Author(s): 橋本道男、Hossain Shahdat、片倉賢紀、紫藤治
  • Organizer: Alzheimer's Association International Conference (AAIC) 2013
  • Place of Presentation: Boston Convention and Exhibition Center (Boston, USA)
• [Presentation] 高齢者の精神神経機能と赤血球膜脂肪酸組成との関連：Shimane CoHRE Study (2013)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、山口修平、並河徹、塩飽邦憲、紫藤治
  • Organizer: 日本脂質栄養学会第22回大会
  • Place of Presentation: 高知会館（高知県高知市）
• [Presentation] 神経幹細胞の分化における多価不飽和脂肪酸受容体, GPR40の役割 (2013)
  • Author(s): 片倉賢紀、橋本道男、奥井俊之、松崎健太郎、紫藤治
  • Organizer: 第65回日本生理学会中国四国地方会
  • Place of Presentation: 川崎医科大学（岡山県倉敷市）
• [Presentation] ω-3多価不飽和脂肪酸による神経変性疾患・精神疾患の予防効果 (2013)
  • Author(s): 片倉賢紀、橋本道男
  • Organizer: 第一回「食と環境、そして高齢化を考える研究会」
  • Place of Presentation: ホテル日航金沢（石川県金沢市）
  • Invited
• [Presentation] 高齢者における青魚摂取と無気力との関連：Shimane CoHRE Study (2013)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、山口修平、並河徹、塩飽邦憲、紫藤治
  • Organizer: 第11回 日本機能性食品医用学会総会
  • Place of Presentation: 東京海洋大学品川キャンパス（東京都品川区）
• [Presentation] 多価不飽和脂肪酸による神経幹細胞の分化制御機構の解析 (2013)
  • Author(s): 片倉賢紀、橋本道男、紫藤治
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Invited
• [Presentation] Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improves learning ability by increasing brain-derived neurotrophic factor levels in a SHR.Cg-Leprcp/NDmcr rats (2013)
  • Author(s): 橋本道男、井上隆之、片倉賢紀、田邊洋子、Abdullah Mamun、紫藤 治
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] Role of G protein-coupled receptor 40, a free fatty acid receptor, in the proliferation and differentiation of cultured neural stem cells (2013)
  • Author(s): Masanori Katakura, Michio Hashimoto, Kentaro Matsuzaki, Toshiyuki Okui, Osamu Shido
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京)
• [Presentation] 長期暑熱馴化下ラットの暑熱耐性形成と視床下部神経新生 (2013)
  • Author(s): Kentaro Matsuzaki, Masanori Katakura, Toshiko Hara, Michio Hashimoto, Osamu Shido
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京)
• [Presentation] Docosahexaenoic acid inhibits amyloid beta peptide fibrillogenesis by inhibiting the formation of di-, tri-, tetra-, and oligomer amyloid intermediate species destined for matured fibers (2012)
  • Author(s): H. Shahdat, M. Hashimoto, M. Katakura, O. Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業(株)研修所(大阪)
• [Presentation] Protective effects of docosahexaenoic acid on cognitive decline with aging and dementia : From animal and human interventional studies (2012)
  • Author(s): M. Hashimoto, H. Shahdat, M. Katakura, O. Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業(株)研修所(大阪)
• [Presentation] Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells (2012)
  • Author(s): M. Katakura, M. Hashimoto, H. Shahdat, O. Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業(株)研修所(大阪)
• [Presentation] 加齢ラット骨格筋に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 井上隆之,橋本道男,片倉賢紀,田邊洋子,Abdullah Al Mamun,松崎健太郎,大谷浩,紫藤治
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学(神奈川)
• [Presentation] 加齢ラット腎臓の多価不飽和脂肪酸代謝物に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、Abdullah Al Mamun、紫藤治
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学(神奈川)
• [Presentation] 若・加齢ラットの認知機能、網膜機能、免疫能、骨格筋に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 橋本道男、片倉賢紀、井上隆之、田邊洋子、十万佐知子、三木和博、海津幸子、谷戸正樹
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学(神奈川)
• [Presentation] Effect of chronic administration of arachidonic acid on skeletal muscle lipids in aged rats (2012)
  • Author(s): T. Inoue, M. Hashimoto, Y. Tanabe, T. Hara, K. Matsuzaki, M. Katakura, H. Otani, O. Shido
  • Place of Presentation: Westin Bayshore Hotel Vancouver(バンクーバー/カナダ)
• [Presentation] Effects of long-term administration of arachidonic acid on spatial cognition in aged rats (2012)
  • Author(s): M. Hashimoto, T. Inoue, Y. Tanabe, A. Mamun, M. Katakura, K. Matsuzaki, O. Shido
  • Organizer: 10th Congress of the international society for the study of fatty acids and lipids (ISSFAL2012)
  • Place of Presentation: Westin Bayshore Hotel Vancouver(バンクーバー/カナダ)
• [Presentation] Conjugated linolenic acid controls neuronal differentiation of cultured neural stem cells by alternating mRNA levels of bHLH transcription factors and cell cycle (2012)
  • Author(s): M. Katakura, T. Okui, M. Hashimoto, K. Matsuzaki, O. Shido
  • Organizer: 10th Congress of the international society for the study of fatty acids and lipids (ISSFAL2012)
  • Place of Presentation: Westin Bayshore Hotel Vancouver(バンクーバー/カナダ)
• [Presentation] Conjugated linolenic acid controls neuronal differentiation of cultured neural stem cells by alternating mRNA levels of bHLH transcription factors and cell cycle (2012)
  • Author(s): Masanori Katakura, Michio Hashimoto, Kentaro Matsuzaki, Osamu Shido
  • Organizer: 10th Congress of the international society for the study of fatty acids and lipids
  • Place of Presentation: Vancouver, CANADA
• [Presentation] Effects of long-term administration of arachidonic acid on spatial cognition in aged rats (2012)
  • Author(s): Hashimoto, Michio, Takayuki Inoue, Yoko Tanabe, Abdullah Al Mamun, Masanori Katakura, Kentaro Matsuzaki, Osamu Shido
  • Organizer: 10th Congress of the international society for the study of fatty acids and lipids
  • Place of Presentation: Vancouver, CANADA
• [Presentation] Effect of chronic administration of arachidonic acid on skeletal muscle lipids in aged rats (2012)
  • Author(s): Inoue, Takayuki; Michio Hashimoto, Yoko Tanabe, Toshiko Hara, Kentaro Matsuzaki, Masanori Katakura, Hiroki Otani, Osamu Shido
  • Organizer: 10th Congress of the international society for the study of fatty acids and lipids
  • Place of Presentation: Vancouver, CANADA
• [Presentation] エゴマ葉減圧マイクロ波乾燥粉末の脂質代謝、骨代謝機能におよぼす影響を検討するヒト介入試験 (2012)
  • Author(s): 橋本道男、山下一也、加藤節司、田邊洋子、井上隆之、片倉賢紀、島田義仁、紫藤治
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学（神奈川県相模原市）
• [Presentation] 若・加齢ラットの認知機能、網膜機能、免疫能、骨格筋に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 橋本道男、片倉賢紀、井上隆之、田邊洋子、十万佐知子、三木和博、海津幸子、谷戸正樹
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学（神奈川県相模原市）
• [Presentation] 加齢ラット腎臓の多価不飽和脂肪酸代謝物に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 片倉賢紀、橋本道男、井上隆之、田邊洋子、Abdullah Al Mamun、紫藤治
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学（神奈川県相模原市）
• [Presentation] 加齢ラット骨格筋に及ぼすアラキドン酸長期投与の影響 (2012)
  • Author(s): 井上隆之，橋本道男，片倉賢紀，田邊洋子，Abdullah Al Mamun，松崎健太郎，大谷 浩，紫藤 治
  • Organizer: 日本脂質栄養学会第21回大会
  • Place of Presentation: 麻布大学（神奈川県相模原市）
• [Presentation] Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells (2012)
  • Author(s): Masanori Katakura, Michio Hashimoto, Hossain Md Shahdat, and Osamu Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業（株）研修所（大阪）
• [Presentation] Protective effects of docosahexaenoic acid on cognitive decline with aging and dementia: From animal and human interventional studies. (2012)
  • Author(s): Michio Hashimoto, Hossain Md Shahdat, Masanori Katakura, and Osamu Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業（株）研修所（大阪）
• [Presentation] Docosahexaenoic acid inhibits amyloid beta peptide fibrillogenesis by inhibiting the formation of di-, tri-, tetra-, and oligomer amyloid intermediate species destined for matured fibers. (2012)
  • Author(s): Hossain Md Shahdat, Michio Hashimoto, Shuji Gamoh, and Osamu Shido
  • Organizer: 第17回武田振興財団生命科学シンポジウム
  • Place of Presentation: 武田薬品工業（株）研修所（大阪）
• [Book] Antioxidant Renoprotective Effects of Hydrogen-rich Water in the SHR.Cg-Lepr^cp/NDmcr Rat-a Metabolic Syndrome Rat Model. Research on Diabetes I (2014)
  • Author(s): Katakura, M & Hashimoto, M
  • Publisher: iConcept Press(ISBN : 978-1-477555-01-9)
• [Book] Research on Diabetes I (2014)
  • Author(s): Masanori Katakura and Michio Hashimoto
  • Total Pages: 12
  • Publisher: iConcept Press
• [Remarks] 島根大学教員情報検索システム
  • URL: https://www.staffsearch.shimane-u.ac.jp/kenkyu/search/detail/1ced59bf6fc49f51c2f902ba654db341/research.html
• [Remarks] 島根大学教員情報検索システム
  • URL: https://www.staffsearch.shimane-u.ac.jp/kenkyu/search/detail/1ced59bf6fc49f51c2f902ba654db341/research.html