The brain mechanism of obesity-induced anxiety and depression: a role of PrRP-synthesizing neurons.

• Project/Area Number: 24790237
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: YOSHIDA Masahide 自治医科大学, 医学部, 助教 (30533955)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ストレス / プロラクチン放出ペプチド / PrRP

Research Abstract

Emotional stress activated prolactin releasing peptide (PrRP)-synthesizing neurons. The medial amygdala-medullary PrRP-synthesizing neuron pathway was suggested to have an important role for neuroendocrine responses to emotional stress. Food intake activates PrRP-synthesizing neurons and endogenous PrRP has anorexic action. Cholecystokinin-PrRP-oxytocin pathway was suggested to play an important role in the control of the termination of each meal.

Research Products

• [Journal Article] Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake. (2013)
  • Author(s): Yamashita,M., Takayanagi,Y., Yoshida,M., Nishimori,K., Kusama, M. and Onaka,T.
  • Journal Title: Journal of Neuroendocrinology Volume: 25 Issue: 5 Pages: 455-465
  • DOI: 10.1111/jne.12019
  • Peer Reviewed
• [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Endocrinology Volume: (in press)
• [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli (2013)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Organizer: The 10th World Congress on Neuro- hypophysial Hormones (WCNH 2013)
  • Place of Presentation: イギリス
  • Year and Date: 2013-07-05
• [Presentation] PrRP-オキシトシン系とリズム (2013)
  • Author(s): 尾仲達史、高柳友紀、山下雅子、吉田匡秀
  • Organizer: 文部科学省私立大学戦略的研究基盤形成支援事業シンポジウム2013
  • Place of Presentation: 日本
  • Year and Date: 2013-06-28
• [Presentation] Importance of the medial amygdala-medullary PrRP synthesizing neurons pathway in neuroendocrine responses to conditioned fear stimuli. (2013)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Organizer: Neuro2013
  • Place of Presentation: 日本
  • Year and Date: 2013-06-20
• [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動 (2013)
  • Author(s): 尾仲達史、高柳友紀、吉田匡秀
  • Organizer: 創薬薬理フォーラム第21回シンポジウム
  • Place of Presentation: 東京, 日本
  • Invited
• [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli (2013)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Organizer: The 10th World Congress on Neuro- hypophysial Hormones (WCNH 2013)
  • Place of Presentation: Bristol, UK
• [Presentation] Importance of the medial amygdala-medullary PrRP synthesizing neurons pathway in neuroendocrine responses to conditioned fear stimuli (2013)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Organizer: Neuro2013
  • Place of Presentation: Kyoto, Japan
• [Remarks]
  • URL: http://www.jichi.ac.jp/usr/pys1/admnpys1/
• [Remarks] 自治医科大学 医学部 生理学講座 神経脳生理部門
  • URL: http://www.jichi.ac.jp/usr/pys1/admnpys1/
• [Remarks] 神経脳生理学｜生理学｜基礎医学部門｜学科目・講座紹介｜医学部の紹介｜医学部｜自治医科大学
  • URL: http://www.jichi.ac.jp/medicine/about/department/basic/physiology/neurology/index.html
• [Remarks] 自治医科大学 神経脳生理学部門
  • URL: http://www.jichi.ac.jp/usr/pys1/admnpys1/index.htm