• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation on the sex difference in the epigenetic regulation of the CRF gene in the hypothalamus

Research Project

Project/Area Number 24790241
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNippon Medical School

Principal Investigator

HIGO Shimpei  日本医科大学, 医学部, 助教 (50623922)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsストレス / 性差 / CRF / stress / epigenomic / sex difference / epigenomics
Research Abstract

Male and female respond differently to various stress. In this study, the epigenetic status of the CRF gene promoter in the praventricular nucleus (PVN) of the hypothalamus of male and female rats were investigated in order to elucidate the underlying mechanisms of the sex differences in the stress response. No sex difference was observed in basal CRF expression in the PVN, whereas the restraint-stress induced increase in the CRF expresson in the female rats were larger than that of the male. Regarding the epigenetic status of the CRF promoter region in the PVN, no sexdifference was observed in the DNA methylation profile, whereas the level of histone acetylation after restraint stress tends to higher in the female. These results indicate the involvement of the histone modification but not DNA methylation in sexdifference in the CRF expression.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (9 results)

  • [Journal Article] Epigenetic supresiion of mouse Per2 expression in the suprachiasmatic nucleus by the inhalation anesthetic, sevoflurane2014

    • Author(s)
      Mori K, Iijima N, Higo S, Aikawa S, Matsuo I, Takumi K, Sakamoto A, Ozawa H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: e87319-e87319

    • DOI

      10.1371/journal.pone.0087319

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus2013

    • Author(s)
      Megumi Anzai
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 3 Pages: 1-9

    • DOI

      10.1371/journal.pone.0059454

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines2013

    • Author(s)
      Kato A, Hojo Y, Higo S, Komatsuzaki Y, Murakami G, Yoshino H, Uebayashi M, Kawato S
    • Journal Title

      Front Neural Circuits

      Volume: 7 Pages: 149-149

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines.2013

    • Author(s)
      Kato A, Hojo Y, Higo S, Komatsuzaki Y, Murakami G, Yoshino H, Uebayashi M, Kawato S.
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 7 Pages: 149-149

    • DOI

      10.3389/fncir.2013.00149

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of the colocalization of corticotropin-releasing hormone receptor and glucocorticoid receptor in kisspeptin neurons in the hypothalamus of female rats2012

    • Author(s)
      Ken Takumi
    • Journal Title

      Neuroscience Letters

      Volume: 531 Issue: 1 Pages: 40-45

    • DOI

      10.1016/j.neulet.2012.10.010

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tome-dependent repression of mPer2 expression in the suprachiasmatic nucleus by inhalation anesthesia with sevoflurane2012

    • Author(s)
      Kadota Kana
    • Journal Title

      Neuroscience Letters

      Volume: 528 Issue: 2 Pages: 153-158

    • DOI

      10.1016/j.neulet.2012.07.061

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development2012

    • Author(s)
      Ken Takumi
    • Journal Title

      Jounal of Physiological Science

      Volume: 62 Issue: 6 Pages: 453-460

    • DOI

      10.1007/s12576-012-0222-y

    • NAID

      10031127103

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 吸入麻酔薬SevofluraneのGABA受容体を介した時計遺伝子への影響2014

    • Author(s)
      松尾いづみ,飯島典生,肥後心平,相川優子,託見健,坂本篤裕,小澤一史
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 吸入麻酔薬SevofluraneのGABA受容体を介した時計遺伝子への影響2014

    • Author(s)
      松尾 いづみ, 相川 優子, 肥後 心平, 飯島 典生, 坂本 篤裕, 小澤 一史
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット泌乳期におけるkisspeptin遺伝子の発現動態制御に関する分子組織化学的解析2013

    • Author(s)
      肥後心平,相川優子,小澤一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松市(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 視床下部kisspeptinニューロンにおけるコルチコトロピン放出ホルモン受容体とグルココルチコイド受容体の発現2013

    • Author(s)
      託見健,飯島典生,肥後心平,小澤一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松市(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 全身麻酔薬セボフルランによるマウス視交叉上核の時計遺伝子mPer2発現抑制に関するエピジェネティック解析2013

    • Author(s)
      森啓介,相川優子,肥後心平,松尾いづみ,飯島典生,坂本篤裕,小澤一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松市(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット泌乳期におけるkisspeptin遺伝子の発現動態制御に関する分子組織化学的解析2013

    • Author(s)
      肥後 心平, 相川 優子, 小澤 一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県 かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 視床下部kisspeptinニューロンにおけるコルチコトロピン放出ホルモン受容体とグルココルチコイド受容体の発現2013

    • Author(s)
      託見 健 , 飯島 典生, 肥後 心平, 小澤 一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県 かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 全身麻酔薬セボフルランによるマウス視交叉上核の時計遺伝子mPer2 発現抑制に関するエピジェネティック解析2013

    • Author(s)
      森 啓介, 相川 優子, 肥後 心平, 松尾 いづみ, 飯島 典生, 坂本 篤裕, 小澤 一史
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県 かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 海馬の神経シナプスを制御する性ステロイド合成と受容体に性差はあるか2012

    • Author(s)
      若林正彦,北条泰嗣,肥後心平,川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市(ポスター)
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi