| Project/Area Number |
24790288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
HATAKEYAMA Jun 熊本大学, 発生医学研究所, 助教 (90404350)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 視交叉上核 / 神経発生 / 核形成 / Dbx1 / 核構造 / 発生 / 国際研究者交流（フランス） / 国際研究者交流フランス / 神経幹細胞 |
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| Research Abstract |
Every kingdom of life-bacteria, plants, and animal- has 24-hours rhythms. In mammal, the suprachaismatic nucleus (SCN) works as a center of the biological clock and the function is well known. However the mechanism of development of that is poorly understood. I found that homeobox genes, Lhx1 and Dbx1, are expressed by differentiating neurons and neural progenitors of SCN respectively. And Ror-alpha is also expressed by differentiating neurons of SCN. In Dbx1 knockout mice, neurons of SCN which are Ror-alpha positive cells were decreased. This result indicated that Dbx1 is important for the formation of SCN.
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