Identification of bacterial factors that determine the host specificity of bordetellosis.

Research Project

Project/Area Number	24790415
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Bacteriology (including Mycology)
Research Institution	Osaka University
Principal Investigator	FUKUI Aya 大阪大学, 微生物病研究所, 特任研究員 (70397743)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	百日咳菌 / 気管支敗血症菌 / 宿主特異性
Research Abstract	The aim of this project was to identify bacterial factors that determine the host specificity of bordetellosis through analyses of the bacterial gene expression during infection by IVET-IP. I established a rat model of bordetella infection, and found that B. pertussis did not colonize rats, suggesting that the original plan of this project would be unsuccessful. Therefore, tried was an alternative plan, in which B. pertussis derivatives that colonize rats are generated by introduction of genes of B. bronchiseptica that shows a wide host range. I expect that genes conferring the wide host range of B. bronchiseptica and determining the host specificity could be identified by this strategy.

Report

(3 results)