| Project/Area Number |
24790422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
MATSUZAWA Takeshi 大阪府立大学, 生命環境科学研究科(系), 助教 (80370154)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 細胞内寄生菌 / 自然免疫 / マクロファージ / インターフェロン / Cell autonomous immunity / インターフェロンγ / 細菌特異的オートファジー / ゼノファジー |
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| Outline of Final Research Achievements |
Macrophages are involved in many essential immune functions, and their role in innate immunity is reinforced by interferon-γ. We previously demonstrated that autophagy, a host degradation system, is mobilized for interferon-γ-mediated cell-autonomous innate immunity against intracellular bacteria. In this study, we found that the recruitment of microtubule-associated protein 1 light chain 3 (LC3), an autophagic marker, to Listeria monocytogenes was increased in interferon-γ-stimulated macrophages compared with untreated macrophages, suggesting that L. monocytogenes was efficiently recognized by autophagy in the interferon-γ-activated macrophages. These results indicate that interferon-γ activates not only basal autophagy but also selective autophagy against intracellular bacteria.
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