| Project/Area Number |
24790425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
ARASAKI Kohei 東京薬科大学, 生命科学部, 助教 (70609990)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | レジオネラ菌 / レジオネラエフェクター / 細胞内膜輸送 / 繋留因子 / 細胞内小胞輸送 / Rabタンパク質 / SNAREタンパク質 |
|---|
| Research Abstract |
Legionella pneumophila (L. pneumophila) is a pathogenic microbe that cause sever pneumonia. In L. pneumophila infection to the host cell, L. pneumophila hijack intracellular trafficking pathway and Legionella effector proteins that are secreted from the L. pneumophila to the host cell play a crucial role in this hijacking. In this study, I revealed that one of the Legionella effector protein, DrrA manipulates exocyst complex (host protein complex) that is implicated in the intracellular trafficking and manipulation of exocyst complex by DrrA is required for the effective intracellular growth of L. pneumophila.
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