| Project/Area Number |
24790428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TANABE Koichi 国立感染症研究所, 国立感染症研究所 真菌部, 主任研究官 (80370964)
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|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 病原真菌 / ステロール / ABCタンパク質 / カンジダ症 / Candida |
|---|
| Research Abstract |
The pathogenic fungus, Candida glabrata is thought to take up exogenous cholesterol inside host body. Exogenous sterol uptake in C. glabrata was activated under iron-depleted conditions. Both ABC protein, AUS1 and mannoprotein, TIR3 was required for sterol uptake. Mouse infection model with AUS1-knockout mutant revealed that sterol uptake was thought to promote the C. glabrata survival inside host tissue.
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