Functional analysis of human herpesvirus 6 (HHV-6) glycoprotein Q1 (gQ1)
| Project/Area Number |
24790442
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kobe University |
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Principal Investigator |
TANG Huamin 神戸大学, 医学(系)研究科(研究院), 助教 (10595896)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 糖タンパク / ＨＨＶ－６ / トロピズム / HHV-6 / gQ1 / 機能ドメイン |
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| Research Abstract |
Human herpesvirus 6 has been reclassified as two virus species because of the huge different character of its clinical isolates. Here we focused gQ1 genes of HHV-6A and -6B, which have been reported to be important for these viruses' entry. We found that HHV-6B gQ1 could not substitute HHV-6A gQ1 function in the infection context. Furthermore, we found that the N terminal of HHV-6A gQ1 contains the site for the binding of CD46, HHV-6A entry receptor. Furthermore we also identified an amino acid residue required for HHV-6B gQ1 function.
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Report
(3 results)
Research Products
(2 results)
