Functional analysis of Bcl11b in T cell development
| Project/Area Number |
24790465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Bcl11b / CD8T細胞 / T細胞 / リンパ球 / 自然免疫 / NKT細胞 / 胸腺 / 分化 |
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| Research Abstract |
The transcription factor Bcl11b plays key roles in T cell development and T cell-mediated immune responses. We examined thymocytes at and after the DP stage in a series of Bcl11b-attenuated mutant mice that carry conditional-knockout and ENU-induced hypomorphic alleles. We show that Bcl11b impairment leads to an increased production of TCRbeta highCD44highCD122high innate CD8+SP thymocytes, which express Eomes and secrete IFN-gamma rapidly after the stimulation with PMA and ionomycin. Since NKT cells in these Bcl11b-mutant mice exhibit developmental arrest at multiple steps, increase of innate CD8SP is not likely to be caused by bystander NKT cells. These results indicate that Bcl11b regulates development of different thymocyte subsets at multiple stages and prevents excessive innate CD8+SP thymocyte differentiation.
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Report
(3 results)
Research Products
(25 results)
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[Presentation] Meis1は表皮幹細胞の維持と皮膚発がんに必要である2013
Author(s)
奥村和弘,齋藤慈,青戸良賢,八谷剛史,榊原康文,葛城美徳,廣瀬哲史,木南凌,後飯塚僚,中村卓郎,若林雄一
Organizer
第34回日本分子生物学会年会
Place of Presentation
神戸
Year and Date
2013-12-04
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