Rapid identification of aminoglycoside resistant bacteria using thiol probe

Research Project

Project/Area Number	24790571
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Laboratory medicine
Research Institution	独立行政法人国立国際医療研究センター
Principal Investigator	ANDO Tomoe 独立行政法人国立国際医療研究センター, その他部局等, 研究員 (80462787)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	薬剤耐性 / 迅速診断 / アミノグリコシド / 緑膿菌 / 迅速検出
Research Abstract	Emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa is serious problem in the medical setting. Rapid detection system for such bacteria is urgently needed. Recently, epidemiological researches have revealed that most of MDR P. aeruginosa is producing aminoglycoside modifying enzyme to acquire aminoglycoside resistances. In this study, I focused on the mechanism of aminoglycoside modifying enzyme function and aimed to develop a rapid detection system for bacteria producing aminoglycoside modifying enzyme using thiol prove.