• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Forensic detection of hypothermic markers in heart, thyroid, adrenal gland using SuperSAGE

Research Project

Project/Area Number 24790641
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionIwate Medical University

Principal Investigator

MASATAKA Takamiya  岩手医科大学, 医学部, 講師 (30364334)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords低体温症 / 副腎 / 心臓 / 分子生物学 / トランスクリプトーム / DNA microarray法 / 定量PCR法 / DNAマイクロアレイ法
Research Abstract

We analyzed the adrenal and cardiac transcriptome of mice killed by hypothermia using DNA microarray technology. In aderenal gland, 2015 genes were upregulated and 2036 were downregulated. In heart, 1704 genes were upregulated and 1734 were downregulated. The present study demonstrated acute adrenal and cardiac responses in hypothermia, and we suggest that understanding adrenal and cardiac mRNA expression would be useful for hypothermia diagnosis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] DNA Microarray Analysis of the Mouse Adrenal Gland for the Detection of Hypothermia Biomarkers : Potential Usefulness for Forensic Investigation2013

    • Author(s)
      Masataka Takamiya, Kiyoshi Saigusa, Koji Dewa
    • Journal Title

      Therapeutic hypothermia and temperature management

      Volume: 3 Pages: 63-73

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA Microarray Analysis of the Mouse Adrenal Gland for the Detection of Hypothermia Biomarkers: Potential Usefulness for Forensic Investigation2013

    • Author(s)
      Masataka Takamiya, Kiyoshi Saigusa, Koji Dewa
    • Journal Title

      Therapeutic hypothermia and temperature management

      Volume: 3 Issue: 2 Pages: 63-73

    • DOI

      10.1089/ther.2013.0001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic transcript profiling in hypothermia using SuperSAGE2012

    • Author(s)
      Masataka Takamiya, Nori Nakayashiki, Koji Dewa
    • Journal Title

      Journal of Forensic & Legal Medicine

      Volume: 19 Pages: 396-401

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 法医病理学におけるバイオマーカー検出を目的とした若干の試み2013

    • Author(s)
      高宮正隆
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2013-06-27
    • Related Report
      2013 Annual Research Report 2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi