Forensic detection of hypothermic markers in heart, thyroid, adrenal gland using SuperSAGE
| Project/Area Number |
24790641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 低体温症 / 副腎 / 心臓 / 分子生物学 / トランスクリプトーム / DNA microarray法 / 定量PCR法 / DNAマイクロアレイ法 |
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| Research Abstract |
We analyzed the adrenal and cardiac transcriptome of mice killed by hypothermia using DNA microarray technology. In aderenal gland, 2015 genes were upregulated and 2036 were downregulated. In heart, 1704 genes were upregulated and 1734 were downregulated. The present study demonstrated acute adrenal and cardiac responses in hypothermia, and we suggest that understanding adrenal and cardiac mRNA expression would be useful for hypothermia diagnosis.
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Report
(3 results)
Research Products
(4 results)
