| Project/Area Number |
24790669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
MITSUNAGA Shuichi 独立行政法人国立がん研究センター, その他部局等, 研究員 (20466197)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 緩和医療 / 膵がん / 悪液質 / 神経浸潤 / RAGE / S100A4 / CCL7 / マウスモデル / アストロサイト / S100P / S100A9 |
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| Research Abstract |
The reaction of the nervous system to neural invasion (N-inv) may lead to cachexia and pain in pancreatic cancer (PCa). The N-inv model was created by injecting Capan-1 cells into the left sciatic nerve of severe combined immunodeficiency mice. The N-inv model was compared to a sham operation group. Propentofylline (PPF), an inhibitor of astrocytic activation, was administered daily into the abdominal cavity. Pain and body weight (BW) were measured weekly. Mice were euthanized 6 weeks after surgery.
Pain and astrocytic activation were observed 2 weeks after the start of N-inv and maintained throughout the experiment. Loss of BW began at 4 weeks and was worse at 6 weeks. PPF treatment inhibited pain, astrocytic activation, and BW loss in the N-inv model. The reaction of the nervous system to N-inv leads to cachexia in PCa. The reaction of the nervous system to N-inv leads to cachexia in PCa.
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