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Development of a novel less invasive therapeutic intervention for early-stage colorectal cancers using cancer-specific targeting agent

Research Project

Project/Area Number 24790700
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionOkayama University

Principal Investigator

KISHIMOTO HIROYUKI  岡山大学, 大学病院, 助教 (50613155)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords消化器内視鏡学 / 大腸癌 / アデノウイルスベクター / 内視鏡治療
Outline of Final Research Achievements

Endoscopic submucosal dissection (ESD) is one of the treatment options for early colorectal cancer. However, cases diagnosed with submucosal (SM) invasion after ESD need surgery. We hypothesized that in SM invasive cases, local tumor resection with a telomerase-dependent tumor killing adenoviral agent (OBP-301) dosing might inhibit LN metastasis. In this study, we assessed whether resection of primary tumor in a similar manner to ESD with prior OBP-301 injection into the peritumoral SM space could purge LN metastasis. Our study demonstrated that OBP-301 could completely eradicate regional LNs metastasis in the SM invasive rectal tumor mouse model with spontaneous LN metastasis by the injection of OBP-301 into the peritumoral submucosal space mimicking the ESD procedures. Virus-mediated biological ablation with the standard ESD technique provides a potential alternative to prophylactic surgery for SM invasive colorectal cancer patients.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results)

  • [Journal Article] Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer.2015

    • Author(s)
      Kikuchi S, Kishimoto H, Tazawa H, Hashimoto Y, Kuroda S, Nishizaki M, Nagasaka T, Shirakawa Y, Kagawa S, Urata Y, Hoffman RM, Fujiwara T.
    • Journal Title

      Mol Ther.

      Volume: 23(3) Issue: 4 Pages: 501-509

    • DOI

      10.1136/gutjnl-2014-306957

    • NAID

      120005537574

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a clinically-precise mouse model of rectal cancer.2013

    • Author(s)
      Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e79453-e79453

    • DOI

      10.1371/journal.pone.0079453

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] テロメラーゼ依存性増殖型アデノウイルス製剤を用いた早期大腸癌の微小リンパ節転移制御2014

    • Author(s)
      菊地覚次、岸本浩行、田澤 大、黒田新士、西崎正彦、香川俊輔、浦田泰生、ロバートホフマン、藤原俊義
    • Organizer
      第73回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular surgery using a novel biological agent, OBP-301, for lymph node micrometastasis in human colorectal cancer.2014

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      2014 ASCO Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2014-05-30 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combination strategy of endoscopic resection and telomerase-targeting oncolytic virus (OBP-301) for eradicating lymph node metastasis of submucosal invasive colorectal cancer2014

    • Author(s)
      Hori N, Kikuchi S, Kishimoto H, et al
    • Organizer
      AACR 2014
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] テロメラーゼ依存性増殖型アデノウイルス製剤を用いた早期大腸癌に対する低侵襲治療の開発2014

    • Author(s)
      菊地覚次、岸本浩行、田澤 大、橋本悠里、宇野 太、西崎正彦、香川俊輔、浦田泰生、ロバートホフマン、藤原俊義
    • Organizer
      第114回日本外科学会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel strategy for eradicating lymph node metastasis of early-stage colorectal cancers using telomerase-dependent replicating adenoviral agent2013

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      第19回日本遺伝子治療学会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] テロメラーゼ依存性増殖型アデノウイルス製剤を用いた早期大腸癌の低侵襲治療の開発2013

    • Author(s)
      菊地覚次、岸本浩行、田澤 大、橋本悠里、宇野 太、西崎正彦、香川俊輔、浦田泰生、ロバートホフマン、藤原俊義
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel strategy for eradicating lymph node metastasis of early-stage colorectal cancers2013

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] がん選択的生物製剤を用いた早期大腸癌の低侵襲治療の開発2013

    • Author(s)
      菊地覚次、岸本浩行、田澤 大、宇野 太、西崎正彦、香川俊輔、浦田泰生、ロバートホフマン、藤原俊義
    • Organizer
      第51回日本癌治療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel strategy for eradicating lymph node metastasis of early-stage colorectal cancers using telomerase-dependent replicating adenoviral agent.2013

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      AACR 2013
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Less invasive therapeutic intervention for early colorectal cancers using telomerase-dependent replicating adenovirus.2013

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel less invasive therapeutic intervention for early-stage colorectal cancers using telomerase-dependent replicating adenoviral agent.2012

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel strategy for eradicating lymph node metastasis of early-stage colorectal cancers using Telomelysin.2012

    • Author(s)
      Kikuchi S, Kishimoto H, et al
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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