Basic studies into development of novel preventive and regenerative therapy for hepatocarcinogenic cirrhosis using bone marrow-derived cells having redox-regulatory capacity
Project/Area Number |
24790703
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Yamaguchi University |
Principal Investigator |
TAKAMI Taro 山口大学, 医学(系)研究科(研究院), 講師 (60511251)
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Research Collaborator |
QUINTANILHA Luiz Fernand 山口大学, 大学院医学系研究科, 助教研究者
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 肝硬変症 / 肝再生療法 / 骨髄細胞 / 酸化ストレス / 肝発癌 / 肝線維化 |
Research Abstract |
We previously developed autologous bone marrow cell infusion (ABMi) therapy, which is a method of liver regeneration for liver cirrhotic patients using non-cultured autologous whole bone marrow cells, and reported the efficacy and safety of this approach. This ABMi therapy was officially approved as an "Advanced Medical Technology B" in Japan. We also reported that frequent bone marrow cell infusion contributed to suppressed tumor initiation during hepatocarcinogenesis. In these studies, we confirmed that hepatocytes co-cultured with bone marrow derived mesenchymal stem cells (MSCs) had lower levels of oxidative stress, and that cirrhotic mice treated with MSCs showed lower levels of liver fibrosis, higher serum antioxidant activity, and lower levels of hepatic malondialdehyde content. These results strongly indicate that cultured BMCs are a stem cell source in liver regeneration therapy for cirrhotic patients.
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Report
(3 results)
Research Products
(58 results)
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[Journal Article] Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy2012
Author(s)
Terai S, Tanimoto H, Maeda M, Zaitsu J, Hisanaga T, Iwamoto T, Fujisawa K, Mizunaga Y, Matsumoto T, Urata Y, Marumoto Y, Hidaka I, Ishikawa T, Yokoyama Y, Aoyama K, Tsuchiya M, Takami T, Omori K, Yamamoto N, Segawa M, Uchida K, Yamasaki T, Okita K, Sakaida I
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Journal Title
J Gastroenterol.
Volume: 47(5)
Pages: 491-497
NAID
Related Report
Peer Reviewed
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[Journal Article] Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy.2012
Author(s)
Terai S, Tanimoto H, Maeda M, Zaitsu J, Hisanaga T, Iwamoto T, Fujisawa K, Mizunaga Y, Matsumoto T, Urata Y, Marumoto Y, Hidaka I, Ishikawa T, Takami T, et al.
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Journal Title
J Gastroenterol.
Volume: 47(5)
Pages: 491-497
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma.2012
Author(s)
Yamasaki T, Saeki I, Harima Y, Zaitsu J, Maeda M, Tanimoto H, Iwamoto T, Hidaka I, Urata Y, Ishikawa T, Takami T, Yamaguchi Y, Uchida K, Terai S, Sakaida I.
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Journal Title
J Gastroenterol.
Volume: 47(6)
Pages: 715-722
NAID
Related Report
Peer Reviewed
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[Presentation] Basic studies for the development of a less invasive liver regeneration therapy using thermoreactive organic/inorganic nanocomposite gels-cultured bone marrow derived cells2012
Author(s)
Takami T, Terai S, Hirose Y, Fujisawa K, Yamamoto N, Takehisa T, Takada T, Haraguchi K, Sakaida I.
Organizer
10th ISSCR Annual meeting
Place of Presentation
Yokohama, Kanagawa, Japan(パシフィコ横浜)
Related Report
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[Book] Liver Resident Stem Cell2012
Author(s)
Takiya CM, Paredes BD, Quintanilha LF, Dias GS, Pinheiro LA, Takami T, Terai S, Sakaida I, Regina SG
Publisher
ELSEVIER
Related Report
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