Chemopreventive effects of metformin for colon carcinogenesis
| Project/Area Number |
24790714
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メトホルミン / 大腸癌 / 化学予防 |
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| Research Abstract |
We prospectively randomized nondiabetic patients with ACF to treatment with metformin or no treatment.The metformin group had a significant decrease in the mean number of ACF per patient, whereas the mean ACF number did not change significantly in the control group. We examined the potential direct effects of metformin on ACF via PCNA immunostaining for colorectal cell proliferative activity and TUNEL for apoptosis. The PCNA index decreased significantly following metformin treatment, although the apoptotic index did not change significantly. These data suggest that metformin effects in suppressing cell proliferation mediate suppressive effects on ACF formation. This first reported trial of metformin for inhibiting colorectal carcinogenesis in humans provides preliminary evidence that metformin suppresses colonic epithelial proliferation and rectal ACF formation in humans.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] aPKClambda/iota is a beneficial prognostic marker for pancreatic neoplasms.2013
Author(s)
Kato S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K, Watanabe S, Sekino Y, Sato T, Sasaki K, Nakaigawa N, Kubota Y, Inayama Y, Endo I, Ohno S, Maeda S, Nakajima A
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Journal Title
Pancreatology
Volume: 13
Issue: 4
Pages: 360-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Inamori MEarly Effect of Single-dose Sitagliptin Administration on Gastric Emptying : Crossover Study Using the (13)C Breath Test2013
Author(s)
Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Hosono K, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi N, Gotoh E, Maeda S, Nakajima A, Nosaka C
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Journal Title
J Neurogastroenterol Motil.
Volume: 19
Issue: 2
Pages: 227-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor diameter and Ki-67 expression in biopsy could be diagnostic markers discriminating from adenoma and early stage cancer in patients with ampullary tumors2013
Author(s)
Kubota K, Fujita Y, Sato T, Watanabe S, Hosono K, Yoneda M, Kirikoshi H, Hisatomi K, Matsuhashi N, Endo I, Inayama Y, Nakajima A
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 20
Issue: 5
Pages: 531-7
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding.2013
Author(s)
Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, Yamada E, Ohkubo H, Higurashi T, Sekino Y, Koide T, Iida H, Hosono K, Nonaka T, Takahashi H, Inamori M, Maeda S, Nakajima A.
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Journal Title
Dig Endosc.
Volume: 25
Issue: 4
Pages: 412-420
DOI
Related Report
Peer Reviewed
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