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2013 Fiscal Year Final Research Report

Chemopreventive effects of metformin for colon carcinogenesis

Research Project

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Project/Area Number 24790714
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionYokohama City University

Principal Investigator

HOSONO Kunihiro  横浜市立大学, 附属病院, 助教 (50537339)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsメトホルミン / 大腸癌 / 化学予防
Research Abstract

We prospectively randomized nondiabetic patients with ACF to treatment with metformin or no treatment.The metformin group had a significant decrease in the mean number of ACF per patient, whereas the mean ACF number did not change significantly in the control group. We examined the potential direct effects of metformin on ACF via PCNA immunostaining for colorectal cell proliferative activity and TUNEL for apoptosis. The PCNA index decreased significantly following metformin treatment, although the apoptotic index did not change significantly. These data suggest that metformin effects in suppressing cell proliferation mediate suppressive effects on ACF formation. This first reported trial of metformin for inhibiting colorectal carcinogenesis in humans provides preliminary evidence that metformin suppresses colonic epithelial proliferation and rectal ACF formation in humans.

  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results)

  • [Journal Article] Covered self-expandable metal stent deployment promises safe neoadjuvant chemoradiation therapy in patients with borderline resectable pancreatic head cancer2014

    • Author(s)
      Kubota K, Sato T, Watanabe S, Hosono K, Kobayashi N, Mori R, Taniguchi K, Matsuyama R, Endo I, Nakajima A
    • Journal Title

      Dig Endosc.

      Volume: 26 Pages: 77-86

    • DOI

      10.1111/den.12049

    • Peer Reviewed
  • [Journal Article] Colon epithelial proliferation and carcinogenesis in diet-induced obesity2013

    • Author(s)
      Takahashi H, Hosono K, Endo H, Nakajima A
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 28 Pages: 41-7

    • DOI

      10.1111/jgh.12240

    • Peer Reviewed
  • [Journal Article] Diagnosis of biliary cystadenoma by peroral video cholangioscopy2013

    • Author(s)
      Watanabe S, Sato T, Hosono K, Kobayashi N, Endo I, Nakayama T, Inayama Y, Nakajima A, Kubota K
    • Journal Title

      Endoscopy

      Volume: 45 Pages: E284-5

    • DOI

      10.1055/s-0033-1344416

    • Peer Reviewed
  • [Journal Article] Positioning of nasobiliary tube using magnet-loaded catheters2013

    • Author(s)
      Watanabe S, Sato T, Kato S, Hosono K, Kobayashi N, Nakajima A, Kubota K
    • Journal Title

      Endoscopy

      Volume: 45 Pages: 835-7

    • DOI

      10.1055/s-0033-1344330

    • Peer Reviewed
  • [Journal Article] aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms2013

    • Author(s)
      Kato S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K, Watanabe S, Sekino Y, Sato T, Sasaki K, Nakaigawa N, Kubota Y, Inayama Y, Endo I, Ohno S, Maeda S, Nakajima A
    • Journal Title

      Pancreatology

      Volume: 13 Pages: 360-8

    • DOI

      10.1016/j.pan.2013.05.006

    • Peer Reviewed
  • [Journal Article] Inamori MEarly Effect of Single-dose Sitagliptin Administration on Gastric Emptying : Crossover Study Using the (13)C Breath Test2013

    • Author(s)
      Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Hosono K, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi N, Gotoh E, Maeda S, Nakajima A, Nosaka C
    • Journal Title

      J Neurogastroenterol Motil.

      Volume: 19 Pages: 227-32

    • DOI

      10.5056/jnm.2013.19.2.227

    • Peer Reviewed
  • [Journal Article] A novel scoring system for arterial invasion of pancreatic body and tail cancer based on multidetector row computed tomography and biomarkers2013

    • Author(s)
      Watanabe S, Kobayashi N, Kubota K, Sato T, Kato S, Hosono K, Shimamura T, Inayama Y, Nakajima A, Endo I
    • Journal Title

      Pancreatology

      Volume: 13 Pages: 161-9

    • DOI

      10.1016/j.pan.2012.12.364

    • Peer Reviewed
  • [Journal Article] Tumor diameter and Ki-67 expression in biopsy could be diagnostic markers discriminating from adenoma and early stage cancer in patients with ampullary tumors2013

    • Author(s)
      Kubota K, Fujita Y, Sato T, Watanabe S, Hosono K, Yoneda M, Kirikoshi H, Hisatomi K, Matsuhashi N, Endo I, Inayama Y, Nakajima A
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Pages: 531-7

    • DOI

      10.1007/s00534-013-0594-2

    • Peer Reviewed
  • [Journal Article] Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding2013

    • Author(s)
      Sakai E, Endo H, Taniguchi L, Hata Y, Ezuka A, Nagase H, Yamada E, Ohkubo H, Higurashi T, Sekino Y, Koide T, Iida H, Hosono K, Nonaka T, Takahashi H, Inamori M, Maeda S, Nakajima A
    • Journal Title

      Dig Endosc.

      Volume: 25 Pages: 412-20

    • DOI

      10.1111/den.12002

    • Peer Reviewed
  • [Journal Article] Needle-knife precut papillotomy with a small incision over a pancreatic stent improves the success rate and reduces the complication rate in difficult biliary cannulations2013

    • Author(s)
      Kubota K, Sato T, Kato S, Watanabe S, Hosono K, Kobayashi N, Hisatomi K, Matsuhashi N, Nakajima A.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 20 Pages: 382-8

    • DOI

      10.1007/s00534-012-0552-4

    • Peer Reviewed
  • [Journal Article] Relationship of human rectal aberrant crypt foci and formation of colorectal polyp : One-year following up after polypectomy2012

    • Author(s)
      Takahashi H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Uchiyama T, Hosono K, Endo H, Nakajima A
    • Journal Title

      World J Gastrointest Endosc.

      Volume: 4 Pages: 561-4

    • DOI

      10.4253/wjge.v4.i12.561

    • Peer Reviewed
  • [Journal Article] Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas2012

    • Author(s)
      Hosono K, Yamada E, Endo H, Takahashi H, Inamori M, Hippo Y, Nakagama H, Nakajima A
    • Journal Title

      World J Gastroenterol.

      Volume: 18 Pages: 5360-8

    • DOI

      10.3748/wjg.v18.i38.5360

    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF) : a double-blind randomized controlled trial2012

    • Author(s)
      Higurashi T, Hosono K, Endo H, Takahashi H, Iida H, Uchiyama T, Ezuka A, Uchiyama S, Yamada E, Ohkubo H, Sakai E, Maeda S, Morita S, Natsumeda Y, Nagase H, Nakajima A
    • Journal Title

      BMC Cancer

      Volume: 12 Pages: 413

    • DOI

      10.1186/1471-2407-12-413

    • Peer Reviewed

URL: 

Published: 2015-06-25  

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