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Epigenetic Analysis of macrophage activation

Research Project

Project/Area Number 24790741
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISAGAWA Takayuki  東京医科歯科大学, 難治疾患研究所, 助教 (40418637)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsmacrophage / inflammation / NFkB / metabolism / マクロファージ / 炎症終息 / NFKB / 代謝
Research Abstract

It is well known that chronic inflammation forms the basis of cancers and the metabolic syndrome. Therefore, in the present study, we performed a comprehensive, genome-wide examination of the targets of NFkBs, the central transcriptional regulator of inflammation, in the context of regulatory mechanisms of inflammation in macrophages. As a result, we revealed that NFkB subunit switching occurs during the transition from the inflammatory response phase to the resolution phase. Furthermore, we found that p50, a NFkB subunit, regulates inflammatory genes during the early inflammatory phase but then shifts to regulating metabolic genes during the resolution phase. We also revealed that p50 is involved in the metabolic reprogramming associated with the inflammatory response.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] Akt1-Mediated Fast/glycolytic Skeletal Muscle Growth Attenuates Renal Damage in Experimental Kidney Disease.2014

    • Author(s)
      Hanatani S, Izumiya Y, Araki S, Rokutanda T, Kimura Y,Walsh K, Ogawa H
    • Journal Title

      J Am Soc Nephrol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014

    • Author(s)
      Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
    • Journal Title

      Can J Cardiol

      Volume: 30 Pages: 338-44

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating thrombospondin-2 reflects disease severity and predicts prognosis of patients with heart failure with reduced ejection fraction2014

    • Author(s)
      Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H
    • Journal Title

      Circ J

      Volume: 78 Pages: 903-10

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts2014

    • Author(s)
      Hanatani S, Izumiya Y, Takashio S, Kojima S, Yamamuro M, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H
    • Journal Title

      Heart Vessels

      Volume: 29 Pages: 231-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic and Prognostic Value of Subcutaneous Tissue Biopsy in Patients with Cardiac Amyloidosis2012

    • Author(s)
      Takashio S, Izumiya Y, Jinnin M, Yamamuro M, Kojima S, Ihn H, Ogawa H
    • Journal Title

      Am J Cardiol

      Volume: 110 Pages: 1507-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling2012

    • Author(s)
      Izumiya Y, Araki S, Usuku H, Rokutanda T, Hanatani S, Ogawa H
    • Journal Title

      Int J Vasc Med

      Volume: 2012 Pages: 146058-146058

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Sirt7 regulates wound healing processes by modulating TGFβ signaling2014

    • Author(s)
      荒木智、泉家康宏、六反田拓、花谷信介、木村優一、小川久雄
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Sirt7 contributes to proper wound healing after cardiovascular injuries by modulating fibroblast differentiation and angiogenic responses.2013

    • Author(s)
      泉家康宏、荒木智、六反田拓、小川久雄
    • Organizer
      第17回日本心不全学会・学術集会
    • Place of Presentation
      大宮ソニックセンター、埼玉
    • Year and Date
      2013-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Sirt7 regulates wound healing by modulating TGFβ signaling.2013

    • Author(s)
      荒木智、泉家康宏、六反田拓、花谷信介、木村優一、小川久雄
    • Organizer
      American Heart Association Scientific Session2013
    • Place of Presentation
      ダラスコンベンションセンター、米国
    • Year and Date
      2013-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Sirt7 is essential for proper wound healing after mouse model of myocardial infarction by modulating TGFβ receptor I degradation.2013

    • Author(s)
      荒木智、泉家康宏、六反田拓、花谷信介、小川久雄
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] マクロファージ炎症収束期におけるNF-kB1/p50の網羅的解析2013

    • Author(s)
      砂河孝行、 真鍋一郎
    • Organizer
      新学術領域研究「自然炎症」+「脂質マシナリー」合同若手ワークショップ
    • Place of Presentation
      ルネッサンスリゾート鳴門
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sirt7 is essential for proper wound healing processes after mouse model of myocardial infarction by inhibiting smad7-medited TGF β receptor I degradation.2012

    • Author(s)
      荒木智、泉家康宏、六反田拓、花谷信介、小川久雄
    • Organizer
      American Heart Association Scientific Session 2012
    • Place of Presentation
      ロサンゼルスコンベンションセンター、 米国
    • Year and Date
      2012-11-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Sirt7 contributes to proper wound healing after cardiovascular injuries by modulating fibroblast differentiation and angiogenic responses.2012

    • Author(s)
      泉家康宏、荒木智、六反田拓、小川久雄
    • Organizer
      日本高血圧学会・シンポジウム
    • Place of Presentation
      ウェスティンナゴヤキャッスル、愛知
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] マクロファージの炎症終息期におけるNFkB1/p50 の網羅的解析2012

    • Author(s)
      砂河 孝行, 眞鍋 一郎, 中山 幸輝, 森岡 勝樹, 武田 憲彦, 永井 良三, 小室 一成
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 炎症性マクロファージを制御する長鎖noncoding RNA(lncRNA)2012

    • Author(s)
      中山 幸輝, 真鍋 一郎, 砂河 孝行, 森岡 勝樹, 永井 良三, 小室 一成
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] マクロファージ低酸素応答におけるエピジェネティック調節機構の役割2012

    • Author(s)
      武田 憲彦, 仙波 宏章, 砂河 孝行, 森岡 勝樹, 安部 元, 相馬 桂, 真鍋 一郎, 永井 良三, 小室 一成
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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