Analysis of the impact of HDL function on coronary artery lesion
Project/Area Number |
24790754
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kyoto University |
Principal Investigator |
IMAI Masao 京都大学, 医学(系)研究科(研究院), 助教 (10625677)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | PCI / DES / HDL / VH-IVUS / 動脈硬化 / PSS / 冠動脈病理 / マイクロRNA |
Outline of Final Research Achievements |
In the present study, to elucidate whether the correlation between HDL quantity and qualitative and also miR-33a and miR33-b is associated with the development of coronary artery lesions. Based on it, we intended to develop new treatment for arteriosclerosis therapy by using improvement of lipid metabolism. Registration of 10 cases were performed percutaneous transluminal coronary angioplasty (PCI) by using virtual histology intravascular ultrasound (VH-IVUS) and after 8-12months we examined follow up CAG by using VH-IVUS again. By performing follow up CAG using VH-IVUS, we can reveal the difference in the composition of cholesterol observed in blood vessel lumen. The amount of change in cholesterol before and after PCI is nothing significantly not only in the VH-IVUS composition, but in the correlation between the change amount of miR-33a and miR33-b.
|
Report
(4 results)
Research Products
(14 results)
-
[Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy2015
Author(s)
Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
-
Journal Title
Circulation Journal
Volume: 79
Issue: 4
Pages: 839-846
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Intravascular ultrasound observation of an obstruction of the left main coronary artery caused by displaced leaflet calcification and hematoma after transcatheter aortic valve implantation.2015
Author(s)
Taniguchi T, Saito N, Minakata K, Imai M, Watanabe H, Toyota T, Watanabe S, Tazaki J, Koizumi S, Hirao S, Yamazaki K, Daijo H, Sakata R, Kimura T
-
Journal Title
Circulation
Volume: 131
Issue: 7
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Noninvasive Detection of Functional Myocardial Ischemia: Multifunction Cardiogram Evaluation in Diagnosis of Functional Coronary Ischemia Study (MED-FIT).2015
Author(s)
Kawaji T, Shiomi H, Morimoto T, Nishikawa R, Yano M, Higami H, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
-
Journal Title
Ann Noninvasive Electrocardiol.
Volume: -
Issue: 5
Pages: 446-453
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Long-term clinical outcomes after sirolimus-eluting stent implantation for unprotected left main coronary artery disease.2014
Author(s)
Higami H, Shiomi H, Niki S, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Shioi T, Ono K, Kimura T.
-
Journal Title
Cardiovasc Interv Ther
Volume: -
Related Report
Peer Reviewed / Open Access
-
[Journal Article] First clinical experience of the looped Inoue balloon technique for antegrade percutaneous balloon aortic valvuloplasty2014
Author(s)
Yano M, Saito N, Watanabe S, Watanabe H, Nishikawa R, Fujino T, Bao B, Yamamoto E, Watanabe H, Nakatsuma K, Imai M, Makiyama T, Sakata Y, Kimura T, Inoue K.
-
Journal Title
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome: mortality and major bleeding in a single-center registry.2014
Author(s)
Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
-
Journal Title
Circ J.
Volume: 78
Pages: 1628-35
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Impact of angiographic peri-stent contrast staining (PSS) on late adverse events after sirolimus-eluting stent implantation: an observation from the multicenter j-Cypher registry PSS substudy.2014
Author(s)
Imai M, Kimura T, Morimoto T, Saito N, Shiomi H, Kawaguchi R, Kan H, Mukawa H, Fujita H, Ishise T, Hayashi F, Nagao K, Take S, Taniguchi H, Sakamoto H, Yamane T, Shirota K, Tamekiyo H, Okamura T, Kishi K, Miyazaki S, Yamamoto S, Yamaji K, Kawasaki T, Taguchi E, Nakajima H, Kosedo I, Tada T, Kadota K, Mitsudo K.
-
Journal Title
Cardiovasc Interv Ther.
Volume: 29
Issue: 3
Pages: 226-36
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] impact of angiographic peri-stent contrast staining (PSS) on late adverse events after sirolimus-eluting stent implantation: an observation from the multicenter j-Cypher registry PSS substudy.2014
Author(s)
Imai M, Kimura T, Morimoto T, Saito N, Shiomi H, Kawaguchi R, Kan H, Mukawa H, Fujita H, Ishise T, Hayashi F, Nagao K, Take S, Taniguchi H, Sakamoto H, Yamane T, Shirota K, Tamekiyo H, Okamura T, Kishi K, Miyazaki S, Yamamoto S, Yamaji K, Kawasaki T, Taguchi E, Nakajima H, Kosedo I, Tada T, Kadota K, Mitsudo K.
-
Journal Title
Cardiovasc Interv Ther.
Volume: Epub ahead of print
NAID
Related Report
Peer Reviewed
-
[Journal Article] Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple-vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2.2013
Author(s)
Tazaki J, Shiomi H, Morimoto T, Imai M, Yamaji K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators.
-
Journal Title
EuroIntervention.
Volume: 9
Issue: 4
Pages: 437-45
DOI
Related Report
Peer Reviewed
-
-
-
-
-