2014 Fiscal Year Final Research Report
Analysis of the impact of HDL function on coronary artery lesion
Project/Area Number |
24790754
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
IMAI Masao 京都大学, 医学(系)研究科(研究院), 助教 (10625677)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | PCI / DES / HDL / VH-IVUS |
Outline of Final Research Achievements |
In the present study, to elucidate whether the correlation between HDL quantity and qualitative and also miR-33a and miR33-b is associated with the development of coronary artery lesions. Based on it, we intended to develop new treatment for arteriosclerosis therapy by using improvement of lipid metabolism. Registration of 10 cases were performed percutaneous transluminal coronary angioplasty (PCI) by using virtual histology intravascular ultrasound (VH-IVUS) and after 8-12months we examined follow up CAG by using VH-IVUS again. By performing follow up CAG using VH-IVUS, we can reveal the difference in the composition of cholesterol observed in blood vessel lumen. The amount of change in cholesterol before and after PCI is nothing significantly not only in the VH-IVUS composition, but in the correlation between the change amount of miR-33a and miR33-b.
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Free Research Field |
Cardiovascular intervention
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