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Effects of ADMA and Light Exposure on Melatonin-Related Blood Pressure Variability

Research Project

Project/Area Number 24790774
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionNara Medical University

Principal Investigator

OBAYASHI Kenji  奈良県立医科大学, 医学部, 助教 (30596656)

Research Collaborator SAEKI Keigo  奈良県立医科大学, 医学部医学科, 講師 (60364056)
TONE Nobuhiro  奈良県立医科大学, 医学部医学科, 特任助手 (50630498)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsメラトニン / ADMA / 夜間血圧 / 交互作用 / サーカディアンリズム / 生体リズム / 光曝露 / 疫学
Outline of Final Research Achievements

Background: Melatonin decreases nighttime blood pressure (BP) by increasing nitric oxide (NO) in endothelial cells. Whether serum asymmetric dimethylarginine (ADMA), a major endogenous competitive inhibitor of endothelial NO synthase, attenuates the association of melatonin with nighttime BP is unclear.
Methods and Results: Serum ADMA, urinary 6-sulfatoxymelatonin excretion (UME), and ambulatory BP were measured in 852 elderly individuals. In the low-ADMA group (n=451), higher UME was inversely associated with adjusted odds ratio for nocturnal hypertension and non-dipper (Q1, 1.00 and 1.00; Q2, 0.92 and 0.74; Q3, 0.57 and 0.51; Q4, 0.48 and 0.40; P=0.004 and 0.002, respectively) but not in the high-ADMA group (n=401) (P=0.75 and 0.12, respectively). These trends were also observed on continuous variable analysis (low ADMA, P=0.031 and 0.003; high ADMA, P=0.52 and 0.13; respectively).
Conclusions: ADMA attenuates the association of endogenous melatonin with night-time BP and dipping.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2015 2014 2013 2012 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Acknowledgement Compliant: 10 results) Presentation (18 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Lower Melatonin Secretion in Older Females: Gender Differences Independent of Light Exposure Profiles2015

    • Author(s)
      Obayashi K, Saeki K, Tone N, Iwamoto J, Miyata K, Ikada Y, Kurumatani N.
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 1 Pages: 38-43

    • DOI

      10.2188/jea.JE20140035

    • NAID

      130004687472

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Light exposure at night is associated with subclinical carotid atherosclerosis in the general elderly population: The HEIJO-KYO cohort2015

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      Chronobiol Int

      Volume: 32 Issue: 3 Pages: 310-317

    • DOI

      10.3109/07420528.2014.974809

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Higher melatonin secretion is associated with lower leukocyte and platelet counts in the general elderly population: the HEIJO-KYO cohort.2015

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      J Pineal Res

      Volume: 58 Issue: 2 Pages: 227-233

    • DOI

      10.1111/jpi.12209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relationship between melatonin secretion and nighttime blood pressure in elderly individuals with and without antihypertensive treatment: a cross-sectional study of the HEIJO-KYO cohort2014

    • Author(s)
      Obayashi K, Saeki K, Tone N, Kurumatani N.
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 10 Pages: 908-913

    • DOI

      10.1038/hr.2014.99

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between urinary 6-sulfatoxymelatonin excretion and arterial stiffness in the general elderly population: the HEIJO-KYO cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 99 Issue: 9 Pages: 3233-3239

    • DOI

      10.1210/jc.2014-1262

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between light exposure at night and insomnia in the general elderly population: the HEIJO-KYO cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      Chronobiol Int

      Volume: 31 Issue: 9 Pages: 976-982

    • DOI

      10.3109/07420528.2014.937491

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relationship between asymmetric dimethylarginine and nocturia in the general elderly population: The HEIJO-KYO cohort.2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      Neurourol Urodyn

      Volume: in press Issue: 8 Pages: 769-773

    • DOI

      10.1002/nau.22647

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N.
    • Journal Title

      Circ J

      Volume: 78 Pages: 2908-2914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stronger association of indoor temperature than outdoor temperature with blood pressure in colder months.2014

    • Author(s)
      Saeki K, Obayashi K, Iwamoto J, Tone N, Okamoto N, Tomioka K, Kurumatani N.
    • Journal Title

      J Hypertens

      Volume: 32 Issue: 8 Pages: 1582-1589

    • DOI

      10.1097/hjh.0000000000000232

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The relationship between indoor, outdoor and ambient temperatures and morning BP surges from inter-seasonally repeated measurements2014

    • Author(s)
      Saeki K, Obayashi K, Iwamoto J, Tone N, Okamoto N, Tomioka K, Kurumatani N.
    • Journal Title

      J Hum Hypertens

      Volume: 28 Issue: 8 Pages: 482-488

    • DOI

      10.1038/jhh.2014.4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Independent Associations of Exposure to Evening Light and Nocturnal Urinary Melatonin Excretion with Diabetes in the Elderly2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N
    • Journal Title

      Chronobiol Int

      Volume: 31 Pages: 394-400

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Exposure to Evening Light on Sleep Initiation in the Elderly: A Longitudinal Analysis for Repeated Measurements in Home Settings2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N
    • Journal Title

      Chronobiol Int

      Volume: 31 Pages: 461-467

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Melatonin Secretion and Nocturia in Elderly Individuals: A Cross-Sectional Study of the HEIJO-KYO Cohort2014

    • Author(s)
      Obayashi K, Saeki K, Kurumatani N
    • Journal Title

      J Urol

      Volume: 191 Pages: 1816-1821

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Light Exposure at Night and Nighttime Blood Pressure in the Elderly Independent of Nocturnal Urinary Melatonin Excretion2014

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N
    • Journal Title

      Chronobiol Int

      Volume: 31 Pages: 779-786

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exposure to Light at Night and Risk of Depression in the Elderly2013

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Ikada Y, Kurumatani N
    • Journal Title

      J Affect Disord

      Volume: 151 Pages: 331-336

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nocturnal urinary melatonin excretion is associated with non-dipper pattern in elderly hypertensives2013

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N.
    • Journal Title

      Hypertens Res

      Volume: 掲載確定 Issue: 8 Pages: 736-40

    • DOI

      10.1038/hr.2013.20

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of room heating on ambulatory blood pressure in winter: a randomised controlled study.2013

    • Author(s)
      Saeki K, Obayashi K, Iwamoto J, Tanaka Y, Tanaka N, Takata S, Kubo H, Okamoto N, Tomioka K, Nezu S, Kurumatani N.
    • Journal Title

      J Epidemiol Community Health

      Volume: 掲載確定 Issue: 6 Pages: 484-490

    • DOI

      10.1136/jech-2012-201883

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exposure to light at night, nocturnal urinary melatonin excretion, and obesity/dyslipidemia in the elderly: a cross-sectional analysis of the HEIJO-KYO study.2013

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98 Issue: 1 Pages: 337-344

    • DOI

      10.1210/jc.2012-2874

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Positive effect of daylight exposure on nocturnal urinary melatonin excretion in the elderly: a cross-sectional analysis of the HEIJO-KYO study.2012

    • Author(s)
      Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 97 Issue: 11 Pages: 4166-4173

    • DOI

      10.1210/jc.2012-1873

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Light Exposure at Night Increases the Risk of Abdominal Obesity: Effect Independent of Melatonin Secretion in the HEIJO-KYO Cohort2015

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、車谷典男
    • Organizer
      米国睡眠学会
    • Place of Presentation
      米国、シアトル
    • Year and Date
      2015-06-06 – 2015-06-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Melatonin Secretion is Associated with Lower Leukocyte and Platelet Counts in Elderly Individuals: The HEIJO-KYO Cohort2015

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、岩本淳子、車谷典男
    • Organizer
      日本疫学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-01-21 – 2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Light Exposure at Night and Metabolic Syndrome in the General Elderly Population: the HEIJO-KYO Cohort2014

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、車谷典男
    • Organizer
      日本時間生物学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 寝室の明るさと動脈硬化の関連:平城京コホートスタディ横断解析2014

    • Author(s)
      大林賢史、佐伯圭吾、車谷典男
    • Organizer
      日本公衆衛生学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日常生活における夜間光曝露量と睡眠障害の関連:住環境に関する大規模疫学調査(平城京スタディ)2014

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩
    • Organizer
      日本建築学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日常生活における日中および夜間光曝露量: 生体リズムに関する高齢者大規模コホート研究(平城京スタディ)の横断解析2014

    • Author(s)
      大林賢史、刀根庸浩、大滝直人、宮田季美恵、西智、佐伯圭吾
    • Organizer
      日本睡眠学会定期学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-02 – 2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exposure to Light at Night in Home Settings and Risk of Insomnia in General Elderly Population: A Cross-Sectional Study in the HEIJO-KYO Cohort2014

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、西智、宮田季美恵、大滝直人、北川麻衣子、車谷典男
    • Organizer
      米国睡眠学会
    • Place of Presentation
      米国、ミネアポリス
    • Related Report
      2013 Research-status Report
  • [Presentation] Exposure to Evening Light, Sleep Initiation, and Obesity in Elderly Individuals: A Cross-Sectional Study in the HEIJO-KYO Cohort2014

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、西智、宮田季美恵、大滝直人、北川麻衣子、野口孝則、餅田尚子、車谷典男
    • Organizer
      米国睡眠学会
    • Place of Presentation
      米国、ミネアポリス
    • Related Report
      2013 Research-status Report
  • [Presentation] Exposure to Evening Light is Associated with Actigraphic Sleep-Onset Latency in the Elderly: A Cross-sectional Analysis of the HEIJO-KYO Study2013

    • Author(s)
      大林賢史、佐伯圭吾、宮田季美恵、刀根庸浩、岩本淳子、岡本希、冨岡公子、車谷典男
    • Organizer
      米国睡眠学会
    • Place of Presentation
      米国、ボルチモア
    • Related Report
      2013 Research-status Report
  • [Presentation] 日中・夜間光曝露量とメラトニン分泌および肥満・脂質異常症との関連: 住環境に関する大規模疫学調査(平城京スタディ)の横断解析2013

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩
    • Organizer
      日本建築学会
    • Place of Presentation
      北海道
    • Related Report
      2013 Research-status Report
  • [Presentation] 高齢者における夜間光曝露と睡眠障害の関連: 生体リズムに関する大規模疫学調査(平城京スタディ)の横断解析2013

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩、宮田季美恵、岩本淳子、岡本希、冨岡公子、車谷典男
    • Organizer
      日本時間生物学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Exposure to Evening Light is Associated with Actigraphic Sleep-Onset Latency in the Elderly: A Cross-sectional Analysis of the HEIJO-KYO Study2013

    • Author(s)
      Kenji Obayashi, Keigo Saeki, Kimie Miyata, Nobuhiro Tone, Junko Iwamoto, Nozomi Okamoto, Kimiko Tomioka, Norio Kurumatani
    • Organizer
      SLEEP, Annual Meeting of the American Professional Sleep Societies
    • Place of Presentation
      Baltimore, US
    • Related Report
      2012 Research-status Report
  • [Presentation] The Impact of Retinal Thickness on Actigraphic Sleep Quality in the Elderly: A Cross-sectional Analysis of the HEIJO-KYO Study2013

    • Author(s)
      Kimie Miyata, Kenji Obayashi, Keigo Saeki, Taiji Hasegawa,Toyoaki Matsuura, Norio Kurumatani, Nahoko Ogata
    • Organizer
      SLEEP, Annual Meeting of the American Professional Sleep Societies
    • Place of Presentation
      Baltimore, US
    • Related Report
      2012 Research-status Report
  • [Presentation] Independent Influences of Actigraphic Sleep Profile and Exposed Temperature on Nocturnal BP Fall among the Elderly: Cross-sectional Analysis of HEIJO-KYO cohort study2013

    • Author(s)
      Keigo Saeki, Kenji Obayashi, Kimie Miyata, Nobuhiro Tone, Junko Iwamoto, Nozomi Okamoto, Kimiko Tomioka, Norio Kurumatani
    • Organizer
      SLEEP, Annual Meeting of the American Professional Sleep Societies
    • Place of Presentation
      Baltimore, US
    • Related Report
      2012 Research-status Report
  • [Presentation] 日中・夜間光曝露量とメラトニン分泌および肥満・脂質異常症との関連 住環境に関する大規模疫学調査(平城京スタディ)の横断解析2013

    • Author(s)
      大林賢史、佐伯圭吾、刀根庸浩
    • Organizer
      日本建築学会総会
    • Place of Presentation
      北海道、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 室温・外気温および曝露温度と自由行動下血圧指標との関連 住環境に関する大規模疫学調査(平城京スタディ)の横断解析2013

    • Author(s)
      佐伯圭吾、大林賢史、刀根庸浩
    • Organizer
      日本建築学会総会
    • Place of Presentation
      北海道、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Inverse dose-response association between urinary melatonin excretion and nocturnal systolic blood pressure in the elderly2012

    • Author(s)
      Kenji Obayashi, Keigo Saeki, Jyunko Iwamoto, Nozomi Okamoto, Kimiko Tomioka, Satoko Nezu, Yoshito Ikada, Norio Kurumatani
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Research-status Report
  • [Presentation] The influence of exposed temperature and physical activity on morning blood pressure surge2012

    • Author(s)
      Keigo Saeki, Kenji Obayashi, Junko Iwamoto, Kimiko Tomioka, Nozomi Okamoto, Satoko Nezu, Norio Kurumatani
    • Organizer
      European Society of Hypertension Annual Meeting
    • Place of Presentation
      London, UK
    • Related Report
      2012 Research-status Report
  • [Remarks] Rearchmap

    • URL

      http://researchmap.jp/obayashi_k/

    • Related Report
      2013 Research-status Report
  • [Remarks] 夜間の豆電球使用が肥満・脂質異常症のリスクになる可能性を示唆

    • URL

      http://www.naramed-u.ac.jp/pdf/news/2013/250109Endocrine-News.pdf

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 生体リズムの測定方法および生体リズム測定装置2013

    • Inventor(s)
      刀根庸浩、佐伯圭吾、大林賢史、高宮祥一
    • Industrial Property Rights Holder
      刀根庸浩、佐伯圭吾、大林賢史、高宮祥一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-31
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] サーカディアンリズムにおける光曝露量の測定方法および測定機器2013

    • Inventor(s)
      刀根庸浩、佐伯圭吾、大林賢史、鈴木信二
    • Industrial Property Rights Holder
      奈良県立医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-01-18
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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