| Project/Area Number |
24790774
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
OBAYASHI Kenji 奈良県立医科大学, 医学部, 助教 (30596656)
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| Research Collaborator |
SAEKI Keigo 奈良県立医科大学, 医学部医学科, 講師 (60364056)
TONE Nobuhiro 奈良県立医科大学, 医学部医学科, 特任助手 (50630498)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メラトニン / ADMA / 夜間血圧 / 交互作用 / サーカディアンリズム / 生体リズム / 光曝露 / 疫学 |
|---|
| Outline of Final Research Achievements |
Background: Melatonin decreases nighttime blood pressure (BP) by increasing nitric oxide (NO) in endothelial cells. Whether serum asymmetric dimethylarginine (ADMA), a major endogenous competitive inhibitor of endothelial NO synthase, attenuates the association of melatonin with nighttime BP is unclear.
Methods and Results: Serum ADMA, urinary 6-sulfatoxymelatonin excretion (UME), and ambulatory BP were measured in 852 elderly individuals. In the low-ADMA group (n=451), higher UME was inversely associated with adjusted odds ratio for nocturnal hypertension and non-dipper (Q1, 1.00 and 1.00; Q2, 0.92 and 0.74; Q3, 0.57 and 0.51; Q4, 0.48 and 0.40; P=0.004 and 0.002, respectively) but not in the high-ADMA group (n=401) (P=0.75 and 0.12, respectively). These trends were also observed on continuous variable analysis (low ADMA, P=0.031 and 0.003; high ADMA, P=0.52 and 0.13; respectively).
Conclusions: ADMA attenuates the association of endogenous melatonin with night-time BP and dipping.
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