Establishment of analysis method of HDL function and its clinical application
| Project/Area Number |
24790789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HDL機能 / コレステロール引き抜き能 / 抗酸化能 / ステント内再狭窄 / 禁煙 / 高比重リポ蛋白(HDL) / HDL機能解析 |
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| Research Abstract |
The major findings of our study are that the cholesterol efflux capacity but not anti-oxidative capacity of HDL was significantly associated with in-stent late loss after stent implantation, and that compared with patients with the higher efflux capacity, patients with the lower efflux capacity demonstrated increased risk of higher in-stent late loss.
We also found that smoking cessation leads to the improvement of HDL functionality (cholesterol efflux capacity and anti-oxidative capacity) without changing HDL-C, apoA-I levels and HDL subfractions.
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Report
(3 results)
Research Products
(18 results)
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[Presentation] Association between HDL functionality and coronary restenosis after stent implantation.2013
Author(s)
Satoshi Imaizumi, Shin-Ichiro Miura, Yosuke Takamiya, Akira Kawamura, Bo Zhang, Atsushi Iwata, Hiroaki Nishikawa, Kunihiro Matsuo, Kazuyuki Shirai, Yoshinari Uehara, Keijiro Saku
Organizer
第7回 Cardio-Diabetes研究会
Place of Presentation
東京
Year and Date
2013-02-23
Related Report
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[Presentation] Relation between HDL Function and Inflammatory/Metabolic Markers in Patients with Coronary Artery Disease (CAD).2013
Author(s)
Takata K, Imaizumi S, Miura S, Takamiya Y, Fukuda Y, Kawamura A, Zhang B, Iwata A, Nishikawa H, Matsuo K, Shirai K, Uehara Y, Reddy ST, Saku K.
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama.
Related Report
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[Presentation] HDL Functionality could be a Novel Marker for Predicting Restenosis after Stent Implantation.2012
Author(s)
Satoshi Imaizumi, Shin-Ichiro Miura, Yosuke Takamiya, Akira Kawamura, Bo Zhang, Atsushi Iwata, Hiroaki Nishikawa, Kunihiro Matsuo, Kazuyuki Shirai, Yoshinari Uehara, Srinivasa T. Reddy, Keijiro Saku
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Los Angeles, California.
Related Report
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