| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The metabolic syndrome is characterized by abdominal obesity, dyslipidemia, hypertension and hyperglycemia. The strength of hyperglycemia condition and a period are conserved in cells by epigenetic changes as “metabolic memory”. In this study, metabolic syndrome model rats were fed on a standard diet for one year three months and the epigenetic changes which induce kidney disease were analyzed by genome-wide DNA methylation states in glomerular vascular endothelial cells. As a result, about 2,000 genes, which decreased DNA methylation at gene promoters by metabolic syndrome, were found as a candidate. This screen revealed 11 genes that were concerned with an inflammation and 6 genes that were concerned formation of angiogenetic and glomerular vascular endothelial cells.
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