| Project/Area Number |
24790863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
OGURA SAYOKO 日本大学, 医学部, 助手 (30618202)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 高血圧 / ストレス / 生理学 / 間欠的低酸素 / 交感神経 / 腎臓 / 循環器・高血圧 |
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| Research Abstract |
The Sleep Apnea Syndrome (SAS) patients are twice as high incidence of hypertension compared with those who are not SAS. However, i the mechanism is for the onset of hypertension is not clear. The experiments were carried out with the aim in particular, to clarify the change in Na reabsorption in the kidney and sustained sympathetic activation by intermittent hypoxia. Blood pressure was not altered by intermittent hypoxia under normal diet, however, it was significantly elevated by high salt diet. The catecholamine contents in several organs were also increased. It is possible that sympathetic nerve activity is enhanced by the intermittent hypoxia and it.might contribute to development of salt sensitive hypertension.
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