The relationship between sympathetic nerve activity and blood pressure of chronic intermittent hypoxia
| Project/Area Number |
24790863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
OGURA SAYOKO 日本大学, 医学部, 助手 (30618202)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 高血圧 / ストレス / 生理学 / 間欠的低酸素 / 交感神経 / 腎臓 / 循環器・高血圧 |
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| Research Abstract |
The Sleep Apnea Syndrome (SAS) patients are twice as high incidence of hypertension compared with those who are not SAS. However, i the mechanism is for the onset of hypertension is not clear. The experiments were carried out with the aim in particular, to clarify the change in Na reabsorption in the kidney and sustained sympathetic activation by intermittent hypoxia. Blood pressure was not altered by intermittent hypoxia under normal diet, however, it was significantly elevated by high salt diet. The catecholamine contents in several organs were also increased. It is possible that sympathetic nerve activity is enhanced by the intermittent hypoxia and it.might contribute to development of salt sensitive hypertension.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor2013
Author(s)
Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida KI, Yatomi Y, Shirai M, Fujita T
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 305
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Peer Reviewed
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[Journal Article] Oxidative Stress in Multiple Organ Damage in Hypertension, Diabetes and CKD, Mechanisms and New Therapeutic Possibilities2012
Author(s)
Shimosawa T, Kaneko T, Qingyou X, Miyamoto Y, Shengyu M, Wang H, Ogura S, Jimbo R, Majtan B, Uetake Y, Hirohama D, Kawakami-Mori F, Fujita T and Yatomi Y
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Journal Title
Oxidative Stress and Diseases
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[Presentation] Strict fluid management prevented left ventricular hypertrophy in long-term peritoneal dialysis patients2012
Author(s)
Daigoro Hirohama, Tatsuo Shimosawa, Yoshitaka Ishibashi, Shengyu Mu, Fumiko Kawakami-Mori, Rika Jimbo, Sayoko Ogura, Yuzaburo Uetake, Yohei Takara, Satoshi Kinugasa, Toshiro Fujita
Organizer
24th Scientific Meeting of International Society of Hypertension
Place of Presentation
Sydney
Year and Date
2012-09-30
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