| Project/Area Number |
24790907
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Toho University (2013)
Chiba University (2012) |
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Principal Investigator |
JIANG Meizi 東邦大学, 医学部, 博士研究員 (00624066)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | メタボリックシンドローム / 脂質代謝異常 / 脂質代謝異常症 / 熱代謝 / 糖尿病 / インスリン抵抗性 / 脂肪分化 |
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| Research Abstract |
Obesity is frequently accompanied with metabolic disorders such as diabetes, dyslipidemia and hypertension. However, the development of accompanied disorders varies largely depending on the genetic factors as well as life-style conditions. Adipose tissues have been largely classified to two types with different histological and physiological properties; white adipose tissue and brown adipose tissue (BAT). Animal studies have shown that the failure in increasing heat production in BAT leads to excess of energy intake compared with energy expenditure. The existence of BAT in adult humans has been recently found using modern imaging techniques. We studied that the role of Lr11 in the production of ectopic differentiation of brown adipocytes in WAT using the knockout mice. The soluble receptor was important for the prevention of the ectopic differentiation of BAT in mice. Our study results contribute to a new treatment development for the obesity-associated diabetes.
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