Clarification of mechanism underlying adipocyte differentiation using a novel model for ectopic accumulation of brown fat tissues

• Project/Area Number: 24790907
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Toho University (2013); Chiba University (2012)
• Principal Investigator: JIANG Meizi 東邦大学, 医学部, 博士研究員 (00624066)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: メタボリックシンドローム / 脂質代謝異常 / 脂質代謝異常症 / 熱代謝 / 糖尿病 / インスリン抵抗性 / 脂肪分化

Research Abstract

Obesity is frequently accompanied with metabolic disorders such as diabetes, dyslipidemia and hypertension. However, the development of accompanied disorders varies largely depending on the genetic factors as well as life-style conditions. Adipose tissues have been largely classified to two types with different histological and physiological properties; white adipose tissue and brown adipose tissue (BAT). Animal studies have shown that the failure in increasing heat production in BAT leads to excess of energy intake compared with energy expenditure. The existence of BAT in adult humans has been recently found using modern imaging techniques. We studied that the role of Lr11 in the production of ectopic differentiation of brown adipocytes in WAT using the knockout mice. The soluble receptor was important for the prevention of the ectopic differentiation of BAT in mice. Our study results contribute to a new treatment development for the obesity-associated diabetes.

Research Products

• [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma (2013)
  • Author(s): Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
  • Journal Title: Br J Haematol Volume: 163(2) Issue: 2 Pages: 277-280
  • DOI: 10.1111/bjh.12467
  • Peer Reviewed
• [Journal Article] Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy (2013)
  • Author(s): Shiba T, Bujo H, Takahashi M, Sato Y, Jiang M, Hori Y, Maeno T, Shirai K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 251(12) Issue: 12 Pages: 2689-95
  • DOI: 10.1007/s00417-013-2373-9
  • Peer Reviewed
• [Journal Article] Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature (2013)
  • Author(s): Alexopoulos P, Guo LH, Jiang M, Bujo H, Grimmer T, Förster S, Drzezga A, Kurz A, Perneczky R
  • Journal Title: J Alzheimers Dis Volume: 36(2) Issue: 2 Pages: 401-8
  • DOI: 10.3233/jad-122329
  • Peer Reviewed
• [Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells (2013)
  • Author(s): Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
  • Journal Title: The Journal of Biological Chemistry Volume: 288(17) Issue: 17 Pages: 11877-11886
  • DOI: 10.1074/jbc.m112.442491
  • Peer Reviewed
• [Journal Article] β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau (2013)
  • Author(s): Tsolakidou A, Alexopoulos P, Guo LH, Grimmer T, Westerteicher C, Kratzer M, Jiang M, Bujo H, Roselli F, Leante MR, Livrea P, Kurz A, Perneczky R
  • Journal Title: Alzheimers Dement Volume: 9(4) Issue: 4 Pages: 386-91
  • DOI: 10.1016/j.jalz.2012.01.015
  • Peer Reviewed
• [Journal Article] Increased circulating soluble LR11 in patients with acute coronary syndrome (2013)
  • Author(s): Ogita M, Miyauchi K, Dohi T, Tsuboi S, Miyazaki T, Yokoyama T, Yokoyama K, Shimada K, Kurata T, Jiang M, Bujo H, Daida H
  • Journal Title: Clin Chim Acta Volume: 16(415) Pages: 191-4
  • DOI: 10.1016/j.cca.2012.10.047
  • Peer Reviewed
• [Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias (2012)
  • Author(s): Sakai S, Nakaseko C, Takeuchi M, Ohwada C, Shimizu N, Tsukamoto S, Kawaguchi T, Jiang M, Sato Y, Ebinuma H, Yokote K, Iwama A, Fukamachi I, Schneider WJ, Saito Y, Bujo H.
  • Journal Title: Clin Chim Acta Volume: 96 Issue: 19-20 Pages: 542-1548
  • DOI: 10.1016/j.cca.2012.06.025
  • Peer Reviewed
• [Journal Article] Circulating Soluble LRU in Patients with Diabetic Retinopathy. (2012)
  • Author(s): Takahashi M, Bujo H, Shiba T, Jiang M, Maeno T, Shirai K
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 1 Pages: 187-192
  • DOI: 10.1016/j.ajo.2012.01.035
  • Peer Reviewed
• [Journal Article] SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease (2012)
  • Author(s): Guo LH, Westerteicher C, Wang XH, Kratzer M, Tsolakidou A, Jiang M, Grimmer T, Laws SM, Alexopoulos P, Bujo H, Kurz A, Perneczky R
  • Journal Title: Eur Arch Psychiatry Clin Neurosci Volume: 262(6) Pages: 529-34
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22286501
  • Peer Reviewed
• [Journal Article] Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease (2012)
  • Author(s): Alexopoulos P, Guo LH, Tsolakidou A, Kratzer M, Grimmer T, Westerteicher C, Jiang M, Bujo H, Diehl-Schmid J, Kurz A, Perneczky R
  • Journal Title: J Alzheimers Dis Volume: 28(3) Issue: 3 Pages: 543-52
  • DOI: 10.3233/jad-2011-110983
  • Peer Reviewed