• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Exploration for Macrophage Derived Steatosis Inducing Factor

Research Project

Project/Area Number 24790910
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

KOBYASHI Masatoshi  東京大学, 医学部附属病院, 研究員 (30396725)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマクロファージ / 脂肪肝 / PPARγ
Research Abstract

We discovered that lipid droplets in cultured rat hepatoma cells were induced with media conditioned by cultured macrophages. We explored the macrophage-derived factors that induced hepatic steatosis. We found that lipid accumulation in hepatocytes accompanied the elevated expressions of Peroxisome Proliferator-Activated Receptor gamma (PPARg) and its target genes. So we examined whether these factors have any activities as PPARg agonists. Furthermore, we investigated variable physical and chemical properties, and prepared the identification of the factor by focusing its category.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi