|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
We discovered that lipid droplets in cultured rat hepatoma cells were induced with media conditioned by cultured macrophages. We explored the macrophage-derived factors that induced hepatic steatosis. We found that lipid accumulation in hepatocytes accompanied the elevated expressions of Peroxisome Proliferator-Activated Receptor gamma (PPARg) and its target genes. So we examined whether these factors have any activities as PPARg agonists. Furthermore, we investigated variable physical and chemical properties, and prepared the identification of the factor by focusing its category.