2013 Fiscal Year Final Research Report
Exploration for Macrophage Derived Steatosis Inducing Factor
| Project/Area Number |
24790910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マクロファージ / 脂肪肝 / PPARγ |
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| Research Abstract |
We discovered that lipid droplets in cultured rat hepatoma cells were induced with media conditioned by cultured macrophages. We explored the macrophage-derived factors that induced hepatic steatosis. We found that lipid accumulation in hepatocytes accompanied the elevated expressions of Peroxisome Proliferator-Activated Receptor gamma (PPARg) and its target genes. So we examined whether these factors have any activities as PPARg agonists. Furthermore, we investigated variable physical and chemical properties, and prepared the identification of the factor by focusing its category.
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