• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of better mouse models of Graves' disease and Grave's ophtahlmopathy

Research Project

Project/Area Number 24790948
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionNagasaki University

Principal Investigator

NAKAHARA Mami  長崎大学, 原爆後障害医療研究所, 客員研究員 (90622605)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords甲状腺自己免疫 / 甲状腺刺激ホルモン受容体 / 国際研究者交流:ドイツ / 国際情報交換、ドイツ
Research Abstract

(1) To determine the appropriate amounts of adenovirus, various amounts of adenovirus were used to immunize mice, revealing that the lower amounts of virus induced higher titers of TSAb and hyperthyroidism, the latter, however, did not last long. (2) Naturally occurring or immunization-induced Graves disease was not observed in mice generated by using SKG and ZAP-70 KO mice having various levels of defects in the signal transduction pathway in T lymphocytes. (3) Experiments of immunization of mice with TSHR + calsequestrin or collagen XIII plus exposure to cigarette smoke revealed that cigarette smoke exacerbated macrophage infiltration in the orbits.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Remarks (2 results)

  • [Journal Article] Disruption of transforming growth factor-・ signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis2014

    • Author(s)
      Shimamura M, Nakahara M, Kurashige T, Yasui K, Nakashima M, Nagayama Y
    • Journal Title

      Endocrine J

      Volume: 61(3) Pages: 297-302

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of transforming growth factor-beta signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis.2014

    • Author(s)
      Shimamura M, Nakahara M, Kurashige T, Yasui K, Nakashima M, Nagayama Y.
    • Journal Title

      Endocrine J

      Volume: 61 Pages: 297-302

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma2013

    • Author(s)
      Shimamura M, Nakahara M, Orim F, Kurashige T, Mitsutake N, Nakashima M, Kondo S, Yamada M, Taguchi R, Kimura S, Nagayama Y
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 11 Pages: 4423-30

    • DOI

      10.1210/en.2013-1174

    • NAID

      120006986735

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice.2012

    • Author(s)
      Nagayama Y, Nakahara M, Shimamura M, Horie I, Arima K, Abiru N.
    • Journal Title

      Clin Exp Immunol

      Volume: 168 Issue: 3 Pages: 268-273

    • DOI

      10.1111/j.1365-2249.2012.04578.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adoptive transfer of antithyrotropin receptor (TSHR) autoimmunity from TSHR knockout mice to athymic nude mice2012

    • Author(s)
      Nakahara M, Johnson K, Eckstein A, Taguchi R, Yamada M, Abiru N, Nagayama Y.
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 4 Pages: 2034-2042

    • DOI

      10.1210/en.2011-1846

    • NAID

      120006985412

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minor contribution of cytotoxic T lymphocyte antigen 4 and programmed cell death 1 ligand 1 in immune tolerance against mouse thyrotropin receptor in mice

    • Author(s)
      Yasui J, Nakahara M, Shimamura M, Kurashige T, Kasui K, Abiru N, Kawakami A, Nagayama Y
    • Journal Title

      Acta Med Nagasaki

      Volume: (in press)

    • NAID

      110009959607

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/index-sjis.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 長崎大学原爆後障害医療研究所

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/index-sjis.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi