Role of Chitin in Allergic Airway Inflammation
Project/Area Number |
24791005
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Kyorin University |
Principal Investigator |
ARAE Ken 杏林大学, 保健学部, 講師 (50306669)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アレルギー / キチン / IL-33 / Th2 |
Research Abstract |
Chitin, b-(1-4)-poly-N-acetyl-D-glucosamine, is a major constituent of the exoskeleton of house dust mites (HDM), raising the possibility that it may be involved in the development of HDM-related allergic disorders. However, the role of chitin in the pathogenesis of allergic disorders is poorly understood. Chitin enhances Th2-type immune responses in airway such as eosinophilia, IgE production and Th2-cytokine production dependently on the IL-33 production and IL-4/IL-13-STAT-6 pathway, resulting in aggravated OVA-induced airway inflammation in mice. In addition, chitin-mediated IL-33 activates pulmonary DCs to induce excessive IL-1b production, and then the DCs enhance the activation of Th2 cells dependently on antigen and IL-1 signaling.
|
Report
(3 results)
Research Products
(8 results)
-
-
[Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma2012
Author(s)
Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S
-
Journal Title
J Immunol
Volume: 189(7)
Pages: 3641-52
URL
Related Report
Peer Reviewed
-
-
[Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice2012
Author(s)
Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
-
Journal Title
Allergology International
Volume: 61
Issue: 2
Pages: 265-273
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
-
[Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012
Author(s)
Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A et al.
-
Journal Title
J Immunol.
Volume: 189
Pages: 3641-3652
Related Report
Peer Reviewed
-
-
-