| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
1)We studied the Bv8mRNA expression of leukocyte in the patient of rheumatoid arthritis(RA). Bv8mRNA expression was elevated in leukocyte of RA patients, especially in high disease activity patients, suggesting that Bv8 may be a marker of disease activity in RA patients.
2) We examined the expression of prokineticin receptor in collagen induced arthritis(CIA) mice and whether Bv8 recruits polymorphonuclear neutrophils (PMNs) and monocytes in vitro and induces inflammatory arthritis in vivo. Prokineticine receptor 2(PKR2) mRNA expression was elevated in CIA mice. Bv8 recruited PMNs in vitro and induced neutrophil-driven inflammatory arthritis. Bv8 may have a previouslly unrecognised pathogenesis in RA by recruiting PMNs. Targeting Bv8 may provide a new therapeutic strategy to treat rheumatoid arthritis.
|
