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Transcriptome analysis of peripheral blood mononuclear cells from patients with IgG4-related disease

Research Project

Project/Area Number 24791011
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKanazawa Medical University

Principal Investigator

NAKAJIMA Akio  金沢医科大学, 医学部, 助教 (80612241)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsIgG4関連疾患 / トランスクリプトーム解析 / 自然免疫 / 制御性T細胞
Outline of Final Research Achievements

IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology. To investigate the pathogenesis of IgG4-RD, this study compared the expression of genes related to innate immunity or regulatory T cells (Tregs) in peripheral blood mononuclear cells (PBMCs) from patients with IgG4-RD and healthy controls. DNA microarray analysis identified 21 genes that showed a greater than 3-fold difference in expression between IgG4-RD patients and healthy controls and 30 genes that showed a greater than 3-fold change in IgG4-RD patients following steroid therapy.
The expression of genes related to innate immunity or Tregs was lower in PBMCs from patients with IgG4-RD than from healthy controls. Although there is the limitation in the number of patients applied in DNA microarray, impaired expression of genes related to innate immunity may be involved in the pathogenesis of IgG4-RD as well as in abnormalities of acquired immunity.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2015 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease2015

    • Author(s)
      Nakajima A, Masaki Y, Nakamura T,et al.
    • Journal Title

      Pros One

      Volume: 10 Issue: 5 Pages: e0126582-e0126582

    • DOI

      10.1371/journal.pone.0126582

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of CLC and MS4A3 gene expression in peripheral blood mononuclear cells from patients with IgG4-related disease.2013

    • Author(s)
      Akio Nakajima
    • Organizer
      12th International Symposium on Sjogren's symdrome
    • Place of Presentation
      Kyoto Hotel Okura, Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] IgG4関連疾患のトランスクリプトーム解析2013

    • Author(s)
      中島 章夫
    • Organizer
      第7回IgG4研究会
    • Place of Presentation
      岡山国際交流センター
    • Related Report
      2012 Research-status Report
  • [Presentation] IgG4関連疾患のトランスクリプトーム解析2012

    • Author(s)
      中島 章夫
    • Organizer
      IgG4キックオフミーティング
    • Place of Presentation
      京都大学芝蘭会館
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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