| Project/Area Number |
24791026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAMURA Shigeki 長崎大学, 医歯(薬)学総合研究科, 助教 (20399752)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感染免疫 / 自然免疫 / インフルエンザ菌 / I型インターフェロン / 細胞内侵入 / 慢性下気道感染症 |
|---|
| Research Abstract |
We examined the mechanism of chronic lower respiratory infection (cLRT) induced by Haemophilus influenzae with focusing the tissue-invasive ability especially bronchial epithelial cells. Twenty-one clinical isolates of H.influenzae were measured the ability of tissue-invasion and there were significant differences of the invasion ability between each strain. In addition, the production of type I IFN in the supernatant of the cell lines infected with high-invasive strains has increased significantly compared to the low-invasive strains.
In general, type I IFN has the inhibitory effect against the viral infection, however we found new insight of type I IFN to accelerate the LRT infection induced with H.influenzae, and this finding will be contribute to elucidate the mechanism of bacterial cLRT.
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