Significance of NKT cell on maintaining homeostasis of lung mucosal innate immunity system during influenza virus infection
| Project/Area Number |
24791030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インフルエンザウイルス / 細菌二次感染 / 好中球 / Ｇ－ＣＳＦ / 自然免疫 |
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| Outline of Final Research Achievements |
Secondly bacteria infection during influenza virus infection is most frequent complication and lethal case in patients. Ｗe examined the immunological mechanisms of impaired immune response against secondly bacterial infection caused by influenza virus infection. When mice with virus were intranasally infected with P. aeruginosa, the faculty of bacterial clearance in lung of viral infected mice significantly decreased compared to that of non-viral infected mice. Neutrophil derived from viral infected mice showed the dysfunction with regard to impaired digestion and/or killing of phagocytized bacteria to due to reduced myeloperoxidase activity. Moreover, G-CSF, which is activator for neutrophil, production in lung of viral infected mice was significantly lower than that of non-viral infected mice after secondly bacteria infection. When viral infected mice was injected with G-CSF before secondly bacteria infection, the faculty of bacteria clearance in viral infected mice was recovered.
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Report
(4 results)
Research Products
(17 results)
