Epidemiology of out of hospital cardiac arrest in school children and the role of school ECG screening

• Project/Area Number: 24791056
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: OHASHI Hiroyuki 三重大学, 医学部附属病院, 助教 (70397511)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心臓性突然死 / 自動体外式除細動器 / 学校心臓検診 / 救急体制 / 学校保健 / 院外心停止

Research Abstract

Hypothesis: We hypothesized that public-access defibrillation (PAD) at school was associated with the improved outcome after out-of-hospital cardiac arrest (OHCA) of cardiac origin (OHCA) in such students at the national level. Methods: We analyzed Japanese Utstein registry and nation-wide survey data of school children during 2005-9. Results: The proportion of patients initially shocked by a bystander among total eligible patients and the proportion of patients with a favorable neurological outcome after OHCA increased. The collapse to defibrillation time was independently associated with a favorable neurological outcome after OHCA. 50% of patients had OHCA at school, which was associated with the event during exercise. OHCA at school was associated with a favorable neurological outcome. Conclusions:PAD at school is associated with a favorable neurological outcome after OHCA in elementary and middle school students at the national level in Japan.

Research Products

• [Journal Article] Circumstances and Outcomes of Out-Of-Hospital Cardiac Arrest in Elementary and Middle School Students in the Era of Public-Access Defibrillation : Implications for Emergency Preparedness in Schools (2014)
  • Author(s): Mitani Y, Ohta K, Ichida F, Nii M, Arakaki Y, Ushinohama H, Takahashi T, Ohashi H, Yodoya N, Fuj ii E, Ishikura K, Tateno S, Sato S, Suzuki T, Higaki T, Iwamoto M, Yoshinaga M, Nagashima M, Sumitomo N
  • Journal Title: Circulation J Volume: 78(3) Pages: 701-707
  • NAID: 130003391007
  • Peer Reviewed
• [Journal Article] Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension. (2014)
  • Author(s): Yamada Y, Maruyama J, Zhang E, Maruyama K. et al
  • Journal Title: J Anesth Volume: 28(1) Issue: 1 Pages: 26-33
  • DOI: 10.1007/s00540-013-1663-z
  • Peer Reviewed
• [Journal Article] Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children : a nationwide, population-based, Utstein registry study in Japan (2013)
  • Author(s): Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y
  • Journal Title: Europace Volume: 15(9) Pages: 1259-1266
  • Peer Reviewed
• [Journal Article] Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children: a nationwide, population-based, Utstein registry study in Japan (2013)
  • Author(s): Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y.
  • Journal Title: Europace Volume: 15 Issue: 9 Pages: 1259-66
  • DOI: 10.1093/europace/eut053
  • Peer Reviewed
• [Journal Article] Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children: a nationwide, population-based, Utstein registry study in Japan. (2013)
  • Author(s): Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y.
  • Journal Title: Europace Volume: １
  • Peer Reviewed
• [Presentation] Early detection of pediatric idiopathic pulmonary arterial hypertension by school electrocardiography screening : a nationwide survey in Japan (2013)
  • Author(s): Sawada H, Mitani Y, Nakayama T, Fukushima H, Kogaki S, Igarashi T, Ichida F, Ono Y, Nakanishi T, Doi S, Ishikawa S, Matsushima M, Yamada O, Saji T
  • Organizer: American Heart Association
  • Place of Presentation: Dallas, USA
  • Year and Date: 2013-11-18
• [Presentation] Phenotypic Modulation of Smooth Muscle Cells and Related Inflammation in the Development of Experimental Obstructive Pulmonary Vasculopathy in Rats (2013)
  • Author(s): Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Yoshida-Imanaka K, Shimpo H, Maruyama K, Komada Y, Mitani Y
  • Organizer: American Heart Association
  • Place of Presentation: 米国
  • Invited
• [Presentation] Reduced BMPR-II Induces GM-CSF Translation and Macrophage Recruitement in Human and Mice, Exacerbating Pulmonary Hypertension (2013)
  • Author(s): Hirofumi Sawada, Yoshihide Mitani, Noriko Yodoya, Shoichiro Otsuki1, Hiroyuki Ohashi, Kazuo Maruyama, Yoshihiro Komada, Marlene Rabinovitch
  • Organizer: 第２回日本肺循環学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 児童生徒の院外心停止における学校心臓検診と学校救急の協力体制の構築に向けて：全国調査からのレッスンと課題 (2013)
  • Author(s): 三谷義英、大橋啓之
  • Organizer: 小児循環器学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Public access defibrillation improved the outcome after out-of-hospital cardiac arrests in school-age children : a nationwide, population-based, Utstein registry study in Japan (2012)
  • Author(s): Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y
  • Organizer: American Heart Association
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2012-11-07
• [Presentation] Public access defibrillation improved the outcome after out-of-hospital cardiac arrests in school-age children: a nationwide, population-based, Utstein registry study in Japan (2012)
  • Author(s): Yoshihide Mitani, Kunio Ohta, Hiroyuki Ohashi, Hirofumi Sawada, Naokata Sumitomo, Yoshihiro Komada,
  • Organizer: American Heart Association
  • Place of Presentation: LA