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Identification of RPS6KA1 as novel molecular target of rhabdomyosarcoma

Research Project

Project/Area Number 24791078
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MIYACHI Mitsuru  京都府立医科大学, 医学(系)研究科(研究院), 助教 (40584983)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsRPS6KA1 / 横紋筋肉腫 / 分子標的療法
Research Abstract

We compared the expression pattern of mouse myoblasts which express rhabdomyosarcoma-specific fusion gene and identified the candidate gene as Rps6ka1. We examined rhabdomyosarcoma tumor specimens and found that RPS6KA1 is overexpressed compared with normal human skeletal muscle. RPS6KA1 inhibitor, BI-D1870, inhibited the proliferation of rhabdomyosarcoma cells and G2/M cell cycle arrest was observed. BI-D1870 treatment induced Myosin Heavy Chain expression and differentiation of rhabdomyosarcoma cells. RPS6KA1 may be a novel therapeutic target of rhabdomyosarcoma.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells2013

    • Author(s)
      Yoshida H, Miyachi M, Hosoi H, et al
    • Journal Title

      Oncogene

      Volume: 11(印刷中) Issue: 49 Pages: 5601-8

    • DOI

      10.1038/onc.2013.491

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] p90 ribosomal S6 kinase1 は横紋筋肉腫における新規分子標的となり得る2012

    • Author(s)
      坂本謙一, 宮地 充, 大内一孝, 土屋邦彦, 家原知子, 細井 創
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] p90 ribosomal S6 kinase 1は横紋筋肉腫における新規分子標的となり得る2012

    • Author(s)
      坂本謙一
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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